Mechanobiology of the relocation of proteins in advecting cells: in vitro experiments, multi-physics modeling, and simulations
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| Tác giả chính: | , , |
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| Định dạng: | Sách |
| Ngôn ngữ: | English |
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Springer
2023
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| Truy cập trực tuyến: | https://link.springer.com/article/10.1007/s10237-023-01717-2 https://dlib.phenikaa-uni.edu.vn/handle/PNK/7998 |
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oai:localhost:PNK-79982023-04-17T07:45:59Z Mechanobiology of the relocation of proteins in advecting cells: in vitro experiments, multi-physics modeling, and simulations M., Serpelloni M., Arricca C., Ravelli Mechanobiology relocation of proteins in advecting cells CC BY Cell motility—a cellular behavior of paramount relevance in embryonic development, immunological response, metastasis, or angiogenesis—demands a mechanical deformation of the cell membrane and influences the surface motion of molecules and their biochemical interactions. In this work, we develop a fully coupled multi-physics model able to capture and predict the protein flow on endothelial advecting plasma membranes. The model has been validated against co-designed in vitro experiments. The complete picture of the receptor dynamics has been understood, and limiting factors have been identified together with the laws that regulate receptor polarization. This computational approach might be insightful in the prediction of endothelial cell behavior in different tumoral environments, circumventing the time-consuming and expensive empirical characterization of each tumor. 2023-04-17T07:45:59Z 2023-04-17T07:45:59Z 2023 Book https://link.springer.com/article/10.1007/s10237-023-01717-2 https://dlib.phenikaa-uni.edu.vn/handle/PNK/7998 en application/pdf Springer |
| institution |
Digital Phenikaa |
| collection |
Digital Phenikaa |
| language |
English |
| topic |
Mechanobiology relocation of proteins in advecting cells |
| spellingShingle |
Mechanobiology relocation of proteins in advecting cells M., Serpelloni M., Arricca C., Ravelli Mechanobiology of the relocation of proteins in advecting cells: in vitro experiments, multi-physics modeling, and simulations |
| description |
CC BY |
| format |
Book |
| author |
M., Serpelloni M., Arricca C., Ravelli |
| author_facet |
M., Serpelloni M., Arricca C., Ravelli |
| author_sort |
M., Serpelloni |
| title |
Mechanobiology of the relocation of proteins in advecting cells: in vitro experiments, multi-physics modeling, and simulations |
| title_short |
Mechanobiology of the relocation of proteins in advecting cells: in vitro experiments, multi-physics modeling, and simulations |
| title_full |
Mechanobiology of the relocation of proteins in advecting cells: in vitro experiments, multi-physics modeling, and simulations |
| title_fullStr |
Mechanobiology of the relocation of proteins in advecting cells: in vitro experiments, multi-physics modeling, and simulations |
| title_full_unstemmed |
Mechanobiology of the relocation of proteins in advecting cells: in vitro experiments, multi-physics modeling, and simulations |
| title_sort |
mechanobiology of the relocation of proteins in advecting cells: in vitro experiments, multi-physics modeling, and simulations |
| publisher |
Springer |
| publishDate |
2023 |
| url |
https://link.springer.com/article/10.1007/s10237-023-01717-2 https://dlib.phenikaa-uni.edu.vn/handle/PNK/7998 |
| _version_ |
1763452660621508608 |
| score |
8.887836 |