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Mechanobiology of the relocation of proteins in advecting cells: in vitro experiments, multi-physics modeling, and simulations

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Bibliographic Details
Main Authors: M., Serpelloni, M., Arricca, C., Ravelli
Format: Book
Language:English
Published: Springer 2023
Subjects:
Mechanobiology
relocation of proteins in advecting cells
Online Access:https://link.springer.com/article/10.1007/s10237-023-01717-2
https://dlib.phenikaa-uni.edu.vn/handle/PNK/7998
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spelling oai:localhost:PNK-79982023-04-17T07:45:59Z Mechanobiology of the relocation of proteins in advecting cells: in vitro experiments, multi-physics modeling, and simulations M., Serpelloni M., Arricca C., Ravelli Mechanobiology relocation of proteins in advecting cells CC BY Cell motility—a cellular behavior of paramount relevance in embryonic development, immunological response, metastasis, or angiogenesis—demands a mechanical deformation of the cell membrane and influences the surface motion of molecules and their biochemical interactions. In this work, we develop a fully coupled multi-physics model able to capture and predict the protein flow on endothelial advecting plasma membranes. The model has been validated against co-designed in vitro experiments. The complete picture of the receptor dynamics has been understood, and limiting factors have been identified together with the laws that regulate receptor polarization. This computational approach might be insightful in the prediction of endothelial cell behavior in different tumoral environments, circumventing the time-consuming and expensive empirical characterization of each tumor. 2023-04-17T07:45:59Z 2023-04-17T07:45:59Z 2023 Book https://link.springer.com/article/10.1007/s10237-023-01717-2 https://dlib.phenikaa-uni.edu.vn/handle/PNK/7998 en application/pdf Springer
institution Digital Phenikaa
collection Digital Phenikaa
language English
topic Mechanobiology
relocation of proteins in advecting cells
spellingShingle Mechanobiology
relocation of proteins in advecting cells
M., Serpelloni
M., Arricca
C., Ravelli
Mechanobiology of the relocation of proteins in advecting cells: in vitro experiments, multi-physics modeling, and simulations
description CC BY
format Book
author M., Serpelloni
M., Arricca
C., Ravelli
author_facet M., Serpelloni
M., Arricca
C., Ravelli
author_sort M., Serpelloni
title Mechanobiology of the relocation of proteins in advecting cells: in vitro experiments, multi-physics modeling, and simulations
title_short Mechanobiology of the relocation of proteins in advecting cells: in vitro experiments, multi-physics modeling, and simulations
title_full Mechanobiology of the relocation of proteins in advecting cells: in vitro experiments, multi-physics modeling, and simulations
title_fullStr Mechanobiology of the relocation of proteins in advecting cells: in vitro experiments, multi-physics modeling, and simulations
title_full_unstemmed Mechanobiology of the relocation of proteins in advecting cells: in vitro experiments, multi-physics modeling, and simulations
title_sort mechanobiology of the relocation of proteins in advecting cells: in vitro experiments, multi-physics modeling, and simulations
publisher Springer
publishDate 2023
url https://link.springer.com/article/10.1007/s10237-023-01717-2
https://dlib.phenikaa-uni.edu.vn/handle/PNK/7998
_version_ 1763452660621508608
score 8.891145

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