Chemical approaches in the development of natural nontoxic peptide Polybia-MP1 as a potential dual antimicrobial and antitumor agent
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| Định dạng: | Bài Báo |
| Ngôn ngữ: | English |
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Amino Acids
2021
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| Truy cập trực tuyến: | https://link.springer.com/article/10.1007/s00726-021-02995-9 https://dlib.phenikaa-uni.edu.vn/handle/PNK/1851 https://doi.org/10.1007/s00726-021-02995-9 |
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oai:localhost:PNK-18512022-08-17T05:54:40Z Chemical approaches in the development of natural nontoxic peptide Polybia-MP1 as a potential dual antimicrobial and antitumor agent Huy L. Xuan Tam D. Duc Anh M. Thuy Phuong M. Chau Truong T. Tung Chemical approaches Natural peptides Peptide AMP Q1 Polybia-MP1 is a well-known natural antimicrobial peptide that has been intensively studied recently due to its therapeutic potential. MP1 exhibited not only potent antibacterial activity but also antifungal and anticancer properties. More importantly, MP1 shows relatively low hemolytic activity compared to other antimicrobial peptides having a similar origin. Thus, besides investigating possible mechanisms of action, great efforts have been invested to develop this peptide to become more “druggable”. In this review, we summarized all the chemical approaches, both success and failure, that using MP1 as a lead compound to create modified analogs with better pharmacological properties. As there have been thousands of natural AMPs found and deposited in numerous databases, such useful information in both the success and failure will provide insight into the research and development of antimicrobial peptides and guiding for the next steps. 2021-06-18T02:37:59Z 2021-06-18T02:37:59Z 2021 Article Working Paper https://link.springer.com/article/10.1007/s00726-021-02995-9 https://dlib.phenikaa-uni.edu.vn/handle/PNK/1851 https://doi.org/10.1007/s00726-021-02995-9 en Amino Acids |
| institution |
Digital Phenikaa |
| collection |
Digital Phenikaa |
| language |
English |
| topic |
Chemical approaches Natural peptides Peptide AMP |
| spellingShingle |
Chemical approaches Natural peptides Peptide AMP Huy L. Xuan Chemical approaches in the development of natural nontoxic peptide Polybia-MP1 as a potential dual antimicrobial and antitumor agent |
| description |
Q1 |
| author2 |
Tam D. Duc |
| author_facet |
Tam D. Duc Huy L. Xuan |
| format |
Article |
| author |
Huy L. Xuan |
| author_sort |
Huy L. Xuan |
| title |
Chemical approaches in the development of natural nontoxic peptide Polybia-MP1 as a potential dual antimicrobial and antitumor agent |
| title_short |
Chemical approaches in the development of natural nontoxic peptide Polybia-MP1 as a potential dual antimicrobial and antitumor agent |
| title_full |
Chemical approaches in the development of natural nontoxic peptide Polybia-MP1 as a potential dual antimicrobial and antitumor agent |
| title_fullStr |
Chemical approaches in the development of natural nontoxic peptide Polybia-MP1 as a potential dual antimicrobial and antitumor agent |
| title_full_unstemmed |
Chemical approaches in the development of natural nontoxic peptide Polybia-MP1 as a potential dual antimicrobial and antitumor agent |
| title_sort |
chemical approaches in the development of natural nontoxic peptide polybia-mp1 as a potential dual antimicrobial and antitumor agent |
| publisher |
Amino Acids |
| publishDate |
2021 |
| url |
https://link.springer.com/article/10.1007/s00726-021-02995-9 https://dlib.phenikaa-uni.edu.vn/handle/PNK/1851 https://doi.org/10.1007/s00726-021-02995-9 |
| _version_ |
1751856253720592384 |
| score |
8.881002 |