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Chemical approaches in the development of natural nontoxic peptide Polybia-MP1 as a potential dual antimicrobial and antitumor agent

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Main Author: Huy L. Xuan
Other Authors: Tam D. Duc
Format: Article
Language:English
Published: Amino Acids 2021
Subjects:
Chemical approaches
Natural peptides
Peptide
AMP
Online Access:https://link.springer.com/article/10.1007/s00726-021-02995-9
https://dlib.phenikaa-uni.edu.vn/handle/PNK/1851
https://doi.org/10.1007/s00726-021-02995-9
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spelling oai:localhost:PNK-18512022-08-17T05:54:40Z Chemical approaches in the development of natural nontoxic peptide Polybia-MP1 as a potential dual antimicrobial and antitumor agent Huy L. Xuan Tam D. Duc Anh M. Thuy Phuong M. Chau Truong T. Tung Chemical approaches Natural peptides Peptide AMP Q1 Polybia-MP1 is a well-known natural antimicrobial peptide that has been intensively studied recently due to its therapeutic potential. MP1 exhibited not only potent antibacterial activity but also antifungal and anticancer properties. More importantly, MP1 shows relatively low hemolytic activity compared to other antimicrobial peptides having a similar origin. Thus, besides investigating possible mechanisms of action, great efforts have been invested to develop this peptide to become more “druggable”. In this review, we summarized all the chemical approaches, both success and failure, that using MP1 as a lead compound to create modified analogs with better pharmacological properties. As there have been thousands of natural AMPs found and deposited in numerous databases, such useful information in both the success and failure will provide insight into the research and development of antimicrobial peptides and guiding for the next steps. 2021-06-18T02:37:59Z 2021-06-18T02:37:59Z 2021 Article Working Paper https://link.springer.com/article/10.1007/s00726-021-02995-9 https://dlib.phenikaa-uni.edu.vn/handle/PNK/1851 https://doi.org/10.1007/s00726-021-02995-9 en Amino Acids
institution Digital Phenikaa
collection Digital Phenikaa
language English
topic Chemical approaches
Natural peptides
Peptide
AMP
spellingShingle Chemical approaches
Natural peptides
Peptide
AMP
Huy L. Xuan
Chemical approaches in the development of natural nontoxic peptide Polybia-MP1 as a potential dual antimicrobial and antitumor agent
description Q1
author2 Tam D. Duc
author_facet Tam D. Duc
Huy L. Xuan
format Article
author Huy L. Xuan
author_sort Huy L. Xuan
title Chemical approaches in the development of natural nontoxic peptide Polybia-MP1 as a potential dual antimicrobial and antitumor agent
title_short Chemical approaches in the development of natural nontoxic peptide Polybia-MP1 as a potential dual antimicrobial and antitumor agent
title_full Chemical approaches in the development of natural nontoxic peptide Polybia-MP1 as a potential dual antimicrobial and antitumor agent
title_fullStr Chemical approaches in the development of natural nontoxic peptide Polybia-MP1 as a potential dual antimicrobial and antitumor agent
title_full_unstemmed Chemical approaches in the development of natural nontoxic peptide Polybia-MP1 as a potential dual antimicrobial and antitumor agent
title_sort chemical approaches in the development of natural nontoxic peptide polybia-mp1 as a potential dual antimicrobial and antitumor agent
publisher Amino Acids
publishDate 2021
url https://link.springer.com/article/10.1007/s00726-021-02995-9
https://dlib.phenikaa-uni.edu.vn/handle/PNK/1851
https://doi.org/10.1007/s00726-021-02995-9
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score 8.881002

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