Polycaprolactone/graphene oxide/acellular matrix nanofibrous scaffolds with antioxidant and promyelinating features for the treatment of peripheral demyelinating diseases
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| Định dạng: | Sách |
| Ngôn ngữ: | English |
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Springer
2023
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| Truy cập trực tuyến: | https://link.springer.com/article/10.1007/s10856-023-06750-2 https://dlib.phenikaa-uni.edu.vn/handle/PNK/9487 |
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oai:localhost:PNK-94872023-10-06T02:57:16Z Polycaprolactone/graphene oxide/acellular matrix nanofibrous scaffolds with antioxidant and promyelinating features for the treatment of peripheral demyelinating diseases Nagarajan, Aishwarya Rizwana, Nasera Abraham, Michelle Polycaprolactone graphene oxide CC-BY Peripheral demyelinating diseases entail damage to axons and Schwann cells in the peripheral nervous system. Because of poor prognosis and lack of a cure, this group of diseases has a global impact. The primary underlying cause of these diseases involves the inability of Schwann cells to remyelinate the damaged insulating myelin around axons, resulting in neuronal death over time. In the past decade, extensive research has been directed in the direction of Schwann cells focusing on their physiological and neuroprotective effects on the neurons in the peripheral nervous system. One cause of dysregulation in the remyelinating function of Schwann cells has been associated with oxidative stress. Tissue-engineered biodegradable scaffolds that can stimulate remyelination response in Schwann cells have been proposed as a potential treatment strategy for peripheral demyelinating diseases. However, strategies developed to date primarily focussed on either remyelination or oxidative stress in isolation. Here, we have developed a multifunctional nanofibrous scaffold with material and biochemical cues to tackle both remyelination and oxidative stress in one matrix. 2023-10-06T02:57:16Z 2023-10-06T02:57:16Z 2023 Book https://link.springer.com/article/10.1007/s10856-023-06750-2 https://dlib.phenikaa-uni.edu.vn/handle/PNK/9487 en application/pdf Springer |
| institution |
Digital Phenikaa |
| collection |
Digital Phenikaa |
| language |
English |
| topic |
Polycaprolactone graphene oxide |
| spellingShingle |
Polycaprolactone graphene oxide Nagarajan, Aishwarya Rizwana, Nasera Abraham, Michelle Polycaprolactone/graphene oxide/acellular matrix nanofibrous scaffolds with antioxidant and promyelinating features for the treatment of peripheral demyelinating diseases |
| description |
CC-BY |
| format |
Book |
| author |
Nagarajan, Aishwarya Rizwana, Nasera Abraham, Michelle |
| author_facet |
Nagarajan, Aishwarya Rizwana, Nasera Abraham, Michelle |
| author_sort |
Nagarajan, Aishwarya |
| title |
Polycaprolactone/graphene oxide/acellular matrix nanofibrous scaffolds with antioxidant and promyelinating features for the treatment of peripheral demyelinating diseases |
| title_short |
Polycaprolactone/graphene oxide/acellular matrix nanofibrous scaffolds with antioxidant and promyelinating features for the treatment of peripheral demyelinating diseases |
| title_full |
Polycaprolactone/graphene oxide/acellular matrix nanofibrous scaffolds with antioxidant and promyelinating features for the treatment of peripheral demyelinating diseases |
| title_fullStr |
Polycaprolactone/graphene oxide/acellular matrix nanofibrous scaffolds with antioxidant and promyelinating features for the treatment of peripheral demyelinating diseases |
| title_full_unstemmed |
Polycaprolactone/graphene oxide/acellular matrix nanofibrous scaffolds with antioxidant and promyelinating features for the treatment of peripheral demyelinating diseases |
| title_sort |
polycaprolactone/graphene oxide/acellular matrix nanofibrous scaffolds with antioxidant and promyelinating features for the treatment of peripheral demyelinating diseases |
| publisher |
Springer |
| publishDate |
2023 |
| url |
https://link.springer.com/article/10.1007/s10856-023-06750-2 https://dlib.phenikaa-uni.edu.vn/handle/PNK/9487 |
| _version_ |
1779307186062622720 |
| score |
8.887836 |