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Polycaprolactone/graphene oxide/acellular matrix nanofibrous scaffolds with antioxidant and promyelinating features for the treatment of peripheral demyelinating diseases

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Main Authors: Nagarajan, Aishwarya, Rizwana, Nasera, Abraham, Michelle
Format: Book
Language:English
Published: Springer 2023
Subjects:
Polycaprolactone
graphene oxide
Online Access:https://link.springer.com/article/10.1007/s10856-023-06750-2
https://dlib.phenikaa-uni.edu.vn/handle/PNK/9487
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spelling oai:localhost:PNK-94872023-10-06T02:57:16Z Polycaprolactone/graphene oxide/acellular matrix nanofibrous scaffolds with antioxidant and promyelinating features for the treatment of peripheral demyelinating diseases Nagarajan, Aishwarya Rizwana, Nasera Abraham, Michelle Polycaprolactone graphene oxide CC-BY Peripheral demyelinating diseases entail damage to axons and Schwann cells in the peripheral nervous system. Because of poor prognosis and lack of a cure, this group of diseases has a global impact. The primary underlying cause of these diseases involves the inability of Schwann cells to remyelinate the damaged insulating myelin around axons, resulting in neuronal death over time. In the past decade, extensive research has been directed in the direction of Schwann cells focusing on their physiological and neuroprotective effects on the neurons in the peripheral nervous system. One cause of dysregulation in the remyelinating function of Schwann cells has been associated with oxidative stress. Tissue-engineered biodegradable scaffolds that can stimulate remyelination response in Schwann cells have been proposed as a potential treatment strategy for peripheral demyelinating diseases. However, strategies developed to date primarily focussed on either remyelination or oxidative stress in isolation. Here, we have developed a multifunctional nanofibrous scaffold with material and biochemical cues to tackle both remyelination and oxidative stress in one matrix. 2023-10-06T02:57:16Z 2023-10-06T02:57:16Z 2023 Book https://link.springer.com/article/10.1007/s10856-023-06750-2 https://dlib.phenikaa-uni.edu.vn/handle/PNK/9487 en application/pdf Springer
institution Digital Phenikaa
collection Digital Phenikaa
language English
topic Polycaprolactone
graphene oxide
spellingShingle Polycaprolactone
graphene oxide
Nagarajan, Aishwarya
Rizwana, Nasera
Abraham, Michelle
Polycaprolactone/graphene oxide/acellular matrix nanofibrous scaffolds with antioxidant and promyelinating features for the treatment of peripheral demyelinating diseases
description CC-BY
format Book
author Nagarajan, Aishwarya
Rizwana, Nasera
Abraham, Michelle
author_facet Nagarajan, Aishwarya
Rizwana, Nasera
Abraham, Michelle
author_sort Nagarajan, Aishwarya
title Polycaprolactone/graphene oxide/acellular matrix nanofibrous scaffolds with antioxidant and promyelinating features for the treatment of peripheral demyelinating diseases
title_short Polycaprolactone/graphene oxide/acellular matrix nanofibrous scaffolds with antioxidant and promyelinating features for the treatment of peripheral demyelinating diseases
title_full Polycaprolactone/graphene oxide/acellular matrix nanofibrous scaffolds with antioxidant and promyelinating features for the treatment of peripheral demyelinating diseases
title_fullStr Polycaprolactone/graphene oxide/acellular matrix nanofibrous scaffolds with antioxidant and promyelinating features for the treatment of peripheral demyelinating diseases
title_full_unstemmed Polycaprolactone/graphene oxide/acellular matrix nanofibrous scaffolds with antioxidant and promyelinating features for the treatment of peripheral demyelinating diseases
title_sort polycaprolactone/graphene oxide/acellular matrix nanofibrous scaffolds with antioxidant and promyelinating features for the treatment of peripheral demyelinating diseases
publisher Springer
publishDate 2023
url https://link.springer.com/article/10.1007/s10856-023-06750-2
https://dlib.phenikaa-uni.edu.vn/handle/PNK/9487
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score 8.891053

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