Polymer–lipid hybrid nanoparticles as potential lipophilic anticancer drug carriers
CC-BY
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| Tác giả chính: | , |
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| Định dạng: | Sách |
| Ngôn ngữ: | English |
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Springer
2023
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| Truy cập trực tuyến: | https://link.springer.com/article/10.1186/s11671-023-03897-3 https://dlib.phenikaa-uni.edu.vn/handle/PNK/9060 |
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oai:localhost:PNK-90602023-09-18T03:21:45Z Polymer–lipid hybrid nanoparticles as potential lipophilic anticancer drug carriers Salel, Sedef Iyisan, Banu drug delivery applications Nanocarrier systems CC-BY Nanocarrier systems are widely used for drug delivery applications, but limitations such as the use of synthetic surfactants, leakage of toxic drugs, and a poor encapsulation capacity remain as challenges. We present a new hybrid nanocarrier system that utilizes natural materials to overcome these limitations and improve the safety and efficacy of drug delivery. The system comprises a biopolymeric shell and a lipid core, encapsulating the lipophilic anticancer drug paclitaxel. Bovine serum albumin and dextran, in various molecular weights, are covalently conjugated via Maillard reaction to form the shell which serves as a stabilizer to maintain nanoparticle integrity. The properties of the system, such as Maillard conjugate concentration, protein/polysaccharide molar ratio, and polysaccharide molecular weight, are optimized to enhance nanoparticle size and stability. 2023-09-18T03:21:45Z 2023-09-18T03:21:45Z 2023 Book https://link.springer.com/article/10.1186/s11671-023-03897-3 https://dlib.phenikaa-uni.edu.vn/handle/PNK/9060 en application/pdf Springer |
| institution |
Digital Phenikaa |
| collection |
Digital Phenikaa |
| language |
English |
| topic |
drug delivery applications Nanocarrier systems |
| spellingShingle |
drug delivery applications Nanocarrier systems Salel, Sedef Iyisan, Banu Polymer–lipid hybrid nanoparticles as potential lipophilic anticancer drug carriers |
| description |
CC-BY |
| format |
Book |
| author |
Salel, Sedef Iyisan, Banu |
| author_facet |
Salel, Sedef Iyisan, Banu |
| author_sort |
Salel, Sedef |
| title |
Polymer–lipid hybrid nanoparticles as potential lipophilic anticancer drug carriers |
| title_short |
Polymer–lipid hybrid nanoparticles as potential lipophilic anticancer drug carriers |
| title_full |
Polymer–lipid hybrid nanoparticles as potential lipophilic anticancer drug carriers |
| title_fullStr |
Polymer–lipid hybrid nanoparticles as potential lipophilic anticancer drug carriers |
| title_full_unstemmed |
Polymer–lipid hybrid nanoparticles as potential lipophilic anticancer drug carriers |
| title_sort |
polymer–lipid hybrid nanoparticles as potential lipophilic anticancer drug carriers |
| publisher |
Springer |
| publishDate |
2023 |
| url |
https://link.springer.com/article/10.1186/s11671-023-03897-3 https://dlib.phenikaa-uni.edu.vn/handle/PNK/9060 |
| _version_ |
1779307151110438912 |
| score |
8.893527 |