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Polymer–lipid hybrid nanoparticles as potential lipophilic anticancer drug carriers

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Bibliographic Details
Main Authors: Salel, Sedef, Iyisan, Banu
Format: Book
Language:English
Published: Springer 2023
Subjects:
drug delivery applications
Nanocarrier systems
Online Access:https://link.springer.com/article/10.1186/s11671-023-03897-3
https://dlib.phenikaa-uni.edu.vn/handle/PNK/9060
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spelling oai:localhost:PNK-90602023-09-18T03:21:45Z Polymer–lipid hybrid nanoparticles as potential lipophilic anticancer drug carriers Salel, Sedef Iyisan, Banu drug delivery applications Nanocarrier systems CC-BY Nanocarrier systems are widely used for drug delivery applications, but limitations such as the use of synthetic surfactants, leakage of toxic drugs, and a poor encapsulation capacity remain as challenges. We present a new hybrid nanocarrier system that utilizes natural materials to overcome these limitations and improve the safety and efficacy of drug delivery. The system comprises a biopolymeric shell and a lipid core, encapsulating the lipophilic anticancer drug paclitaxel. Bovine serum albumin and dextran, in various molecular weights, are covalently conjugated via Maillard reaction to form the shell which serves as a stabilizer to maintain nanoparticle integrity. The properties of the system, such as Maillard conjugate concentration, protein/polysaccharide molar ratio, and polysaccharide molecular weight, are optimized to enhance nanoparticle size and stability. 2023-09-18T03:21:45Z 2023-09-18T03:21:45Z 2023 Book https://link.springer.com/article/10.1186/s11671-023-03897-3 https://dlib.phenikaa-uni.edu.vn/handle/PNK/9060 en application/pdf Springer
institution Digital Phenikaa
collection Digital Phenikaa
language English
topic drug delivery applications
Nanocarrier systems
spellingShingle drug delivery applications
Nanocarrier systems
Salel, Sedef
Iyisan, Banu
Polymer–lipid hybrid nanoparticles as potential lipophilic anticancer drug carriers
description CC-BY
format Book
author Salel, Sedef
Iyisan, Banu
author_facet Salel, Sedef
Iyisan, Banu
author_sort Salel, Sedef
title Polymer–lipid hybrid nanoparticles as potential lipophilic anticancer drug carriers
title_short Polymer–lipid hybrid nanoparticles as potential lipophilic anticancer drug carriers
title_full Polymer–lipid hybrid nanoparticles as potential lipophilic anticancer drug carriers
title_fullStr Polymer–lipid hybrid nanoparticles as potential lipophilic anticancer drug carriers
title_full_unstemmed Polymer–lipid hybrid nanoparticles as potential lipophilic anticancer drug carriers
title_sort polymer–lipid hybrid nanoparticles as potential lipophilic anticancer drug carriers
publisher Springer
publishDate 2023
url https://link.springer.com/article/10.1186/s11671-023-03897-3
https://dlib.phenikaa-uni.edu.vn/handle/PNK/9060
_version_ 1779307151110438912
score 8.891145

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