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Green synthesis of oncolytic Newcastle disease virus-loaded thiolated chitosan nanoformulation for CD44 targeted delivery and sustained release of virus in cervical cancer xenografts

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Bibliographic Details
Main Authors: Kousar, Kousain, Naseer, Faiza, Abduh, Maisa S.
Format: Book
Language:English
Published: Springer 2023
Subjects:
NDV
acid for CD44
Online Access:https://link.springer.com/article/10.1186/s12645-023-00220-8
https://dlib.phenikaa-uni.edu.vn/handle/PNK/8949
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spelling oai:localhost:PNK-89492023-08-25T04:48:39Z Green synthesis of oncolytic Newcastle disease virus-loaded thiolated chitosan nanoformulation for CD44 targeted delivery and sustained release of virus in cervical cancer xenografts Kousar, Kousain Naseer, Faiza Abduh, Maisa S. NDV acid for CD44 CC-BY Newcastle disease virus (NDV) Lasota strain has proven oncolytic activity. One shortcoming associated with this treatment modality is the immune neutralization of the virus in body, mediated by natural killer cells and macrophages. This study aims at encapsulating the oncolytic virus in thiolated chitosan nanoparticles, surface functionalized with hyaluronic acid for CD44 targeted delivery and sustained release of NDV in cervical cancer tumors. These nanoparticles were tested for oncolytic potential in HeLa cells and cervical cancer xenograft model. 2023-08-25T04:48:39Z 2023-08-25T04:48:39Z 2023 Book https://link.springer.com/article/10.1186/s12645-023-00220-8 https://dlib.phenikaa-uni.edu.vn/handle/PNK/8949 en application/pdf Springer
institution Digital Phenikaa
collection Digital Phenikaa
language English
topic NDV
acid for CD44
spellingShingle NDV
acid for CD44
Kousar, Kousain
Naseer, Faiza
Abduh, Maisa S.
Green synthesis of oncolytic Newcastle disease virus-loaded thiolated chitosan nanoformulation for CD44 targeted delivery and sustained release of virus in cervical cancer xenografts
description CC-BY
format Book
author Kousar, Kousain
Naseer, Faiza
Abduh, Maisa S.
author_facet Kousar, Kousain
Naseer, Faiza
Abduh, Maisa S.
author_sort Kousar, Kousain
title Green synthesis of oncolytic Newcastle disease virus-loaded thiolated chitosan nanoformulation for CD44 targeted delivery and sustained release of virus in cervical cancer xenografts
title_short Green synthesis of oncolytic Newcastle disease virus-loaded thiolated chitosan nanoformulation for CD44 targeted delivery and sustained release of virus in cervical cancer xenografts
title_full Green synthesis of oncolytic Newcastle disease virus-loaded thiolated chitosan nanoformulation for CD44 targeted delivery and sustained release of virus in cervical cancer xenografts
title_fullStr Green synthesis of oncolytic Newcastle disease virus-loaded thiolated chitosan nanoformulation for CD44 targeted delivery and sustained release of virus in cervical cancer xenografts
title_full_unstemmed Green synthesis of oncolytic Newcastle disease virus-loaded thiolated chitosan nanoformulation for CD44 targeted delivery and sustained release of virus in cervical cancer xenografts
title_sort green synthesis of oncolytic newcastle disease virus-loaded thiolated chitosan nanoformulation for cd44 targeted delivery and sustained release of virus in cervical cancer xenografts
publisher Springer
publishDate 2023
url https://link.springer.com/article/10.1186/s12645-023-00220-8
https://dlib.phenikaa-uni.edu.vn/handle/PNK/8949
_version_ 1775230274603319296
score 8.887836

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