Topically applied fullerenols protect against radiation dermatitis by scavenging reactive oxygen species
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| Ngôn ngữ: | English |
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Springer
2023
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| Truy cập trực tuyến: | https://link.springer.com/article/10.1186/s11671-023-03869-7 https://dlib.phenikaa-uni.edu.vn/handle/PNK/8946 |
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oai:localhost:PNK-89462023-08-25T04:02:49Z Topically applied fullerenols protect against radiation dermatitis by scavenging reactive oxygen species Yin, Hanying Gao, You Chen, Weiguang RD ROS CC_BY Adverse skin reactions caused by ionizing radiation are collectively called radiation dermatitis (RD), and the use of nanomedicine is an attractive approach to this condition. Therefore, we designed and large-scale synthesized fullerenols that showed free radical scavenging ability in vitro. Next, we pretreated X-ray-exposed cells with fullerenols. The results showed that pretreatment with fullerenols significantly scavenged intracellular reactive oxygen species (ROS) produced and enhanced the antioxidant capacity, protecting skin cells from X-ray-induced DNA damage and apoptosis. Moreover, we induced RD in mice by applying 30 Gy of X-ray irradiation, followed by treatment with fullerenols. We found that after treatment, the RD scores dropped, and the histological results systematically demonstrated that topically applied fullerenols could reduce radiation-induced skin epidermal thickening, collagen deposition and skin appendage damage and promote hair regeneration after 35 days. 2023-08-25T04:02:49Z 2023-08-25T04:02:49Z 2023 Book https://link.springer.com/article/10.1186/s11671-023-03869-7 https://dlib.phenikaa-uni.edu.vn/handle/PNK/8946 en application/pdf Springer |
| institution |
Digital Phenikaa |
| collection |
Digital Phenikaa |
| language |
English |
| topic |
RD ROS |
| spellingShingle |
RD ROS Yin, Hanying Gao, You Chen, Weiguang Topically applied fullerenols protect against radiation dermatitis by scavenging reactive oxygen species |
| description |
CC_BY |
| format |
Book |
| author |
Yin, Hanying Gao, You Chen, Weiguang |
| author_facet |
Yin, Hanying Gao, You Chen, Weiguang |
| author_sort |
Yin, Hanying |
| title |
Topically applied fullerenols protect against radiation dermatitis by scavenging reactive oxygen species |
| title_short |
Topically applied fullerenols protect against radiation dermatitis by scavenging reactive oxygen species |
| title_full |
Topically applied fullerenols protect against radiation dermatitis by scavenging reactive oxygen species |
| title_fullStr |
Topically applied fullerenols protect against radiation dermatitis by scavenging reactive oxygen species |
| title_full_unstemmed |
Topically applied fullerenols protect against radiation dermatitis by scavenging reactive oxygen species |
| title_sort |
topically applied fullerenols protect against radiation dermatitis by scavenging reactive oxygen species |
| publisher |
Springer |
| publishDate |
2023 |
| url |
https://link.springer.com/article/10.1186/s11671-023-03869-7 https://dlib.phenikaa-uni.edu.vn/handle/PNK/8946 |
| _version_ |
1775230274290843648 |
| score |
8.887836 |