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Topically applied fullerenols protect against radiation dermatitis by scavenging reactive oxygen species

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Bibliographic Details
Main Authors: Yin, Hanying, Gao, You, Chen, Weiguang
Format: Book
Language:English
Published: Springer 2023
Subjects:
RD
ROS
Online Access:https://link.springer.com/article/10.1186/s11671-023-03869-7
https://dlib.phenikaa-uni.edu.vn/handle/PNK/8946
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spelling oai:localhost:PNK-89462023-08-25T04:02:49Z Topically applied fullerenols protect against radiation dermatitis by scavenging reactive oxygen species Yin, Hanying Gao, You Chen, Weiguang RD ROS CC_BY Adverse skin reactions caused by ionizing radiation are collectively called radiation dermatitis (RD), and the use of nanomedicine is an attractive approach to this condition. Therefore, we designed and large-scale synthesized fullerenols that showed free radical scavenging ability in vitro. Next, we pretreated X-ray-exposed cells with fullerenols. The results showed that pretreatment with fullerenols significantly scavenged intracellular reactive oxygen species (ROS) produced and enhanced the antioxidant capacity, protecting skin cells from X-ray-induced DNA damage and apoptosis. Moreover, we induced RD in mice by applying 30 Gy of X-ray irradiation, followed by treatment with fullerenols. We found that after treatment, the RD scores dropped, and the histological results systematically demonstrated that topically applied fullerenols could reduce radiation-induced skin epidermal thickening, collagen deposition and skin appendage damage and promote hair regeneration after 35 days. 2023-08-25T04:02:49Z 2023-08-25T04:02:49Z 2023 Book https://link.springer.com/article/10.1186/s11671-023-03869-7 https://dlib.phenikaa-uni.edu.vn/handle/PNK/8946 en application/pdf Springer
institution Digital Phenikaa
collection Digital Phenikaa
language English
topic RD
ROS
spellingShingle RD
ROS
Yin, Hanying
Gao, You
Chen, Weiguang
Topically applied fullerenols protect against radiation dermatitis by scavenging reactive oxygen species
description CC_BY
format Book
author Yin, Hanying
Gao, You
Chen, Weiguang
author_facet Yin, Hanying
Gao, You
Chen, Weiguang
author_sort Yin, Hanying
title Topically applied fullerenols protect against radiation dermatitis by scavenging reactive oxygen species
title_short Topically applied fullerenols protect against radiation dermatitis by scavenging reactive oxygen species
title_full Topically applied fullerenols protect against radiation dermatitis by scavenging reactive oxygen species
title_fullStr Topically applied fullerenols protect against radiation dermatitis by scavenging reactive oxygen species
title_full_unstemmed Topically applied fullerenols protect against radiation dermatitis by scavenging reactive oxygen species
title_sort topically applied fullerenols protect against radiation dermatitis by scavenging reactive oxygen species
publisher Springer
publishDate 2023
url https://link.springer.com/article/10.1186/s11671-023-03869-7
https://dlib.phenikaa-uni.edu.vn/handle/PNK/8946
_version_ 1775230274290843648
score 8.891145

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