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Morphological parameters affecting false lumen thrombosis following type B aortic dissection: a systematic study based on simulations of idealized models

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Bibliographic Details
Main Authors: Alireza, Jafarinia, Gian Marco, Melito, Thomas Stephan, Müller
Format: Book
Language:English
Published: Springer 2023
Subjects:
TBAD
FL
Online Access:https://link.springer.com/article/10.1007/s10237-023-01687-5
https://dlib.phenikaa-uni.edu.vn/handle/PNK/8504
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spelling oai:localhost:PNK-85042023-05-25T03:47:39Z Morphological parameters affecting false lumen thrombosis following type B aortic dissection: a systematic study based on simulations of idealized models Alireza, Jafarinia Gian Marco, Melito Thomas Stephan, Müller TBAD FL CC BY Type B aortic dissection (TBAD) carries a high risk of complications, particularly with a partially thrombosed or patent false lumen (FL). Therefore, uncovering the risk factors leading to FL thrombosis is crucial to identify high-risk patients. Although studies have shown that morphological parameters of the dissected aorta are related to FL thrombosis, often conflicting results have been reported. We show that recent models of thrombus evolution in combination with sensitivity analysis methods can provide valuable insights into how combinations of morphological parameters affect the prospect of FL thrombosis. Based on clinical data, an idealized geometry of a TBAD is generated and parameterized. After implementing the thrombus model in computational fluid dynamics simulations, a global sensitivity analysis for selected morphological parameters is performed. We then introduce dimensionless morphological parameters to scale the results to individual patients. 2023-05-25T03:47:39Z 2023-05-25T03:47:39Z 2023 Book https://link.springer.com/article/10.1007/s10237-023-01687-5 https://dlib.phenikaa-uni.edu.vn/handle/PNK/8504 en application/pdf Springer
institution Digital Phenikaa
collection Digital Phenikaa
language English
topic TBAD
FL
spellingShingle TBAD
FL
Alireza, Jafarinia
Gian Marco, Melito
Thomas Stephan, Müller
Morphological parameters affecting false lumen thrombosis following type B aortic dissection: a systematic study based on simulations of idealized models
description CC BY
format Book
author Alireza, Jafarinia
Gian Marco, Melito
Thomas Stephan, Müller
author_facet Alireza, Jafarinia
Gian Marco, Melito
Thomas Stephan, Müller
author_sort Alireza, Jafarinia
title Morphological parameters affecting false lumen thrombosis following type B aortic dissection: a systematic study based on simulations of idealized models
title_short Morphological parameters affecting false lumen thrombosis following type B aortic dissection: a systematic study based on simulations of idealized models
title_full Morphological parameters affecting false lumen thrombosis following type B aortic dissection: a systematic study based on simulations of idealized models
title_fullStr Morphological parameters affecting false lumen thrombosis following type B aortic dissection: a systematic study based on simulations of idealized models
title_full_unstemmed Morphological parameters affecting false lumen thrombosis following type B aortic dissection: a systematic study based on simulations of idealized models
title_sort morphological parameters affecting false lumen thrombosis following type b aortic dissection: a systematic study based on simulations of idealized models
publisher Springer
publishDate 2023
url https://link.springer.com/article/10.1007/s10237-023-01687-5
https://dlib.phenikaa-uni.edu.vn/handle/PNK/8504
_version_ 1772331160520622080
score 8.891695

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