Design, synthesis and antitumor activity of new naproxen based 1,2,4-triazole-Schiff base derivatives
CC BY
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| Định dạng: | Sách |
| Ngôn ngữ: | English |
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Springer
2023
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| Truy cập trực tuyến: | https://link.springer.com/article/10.1007/s43994-023-00044-7 https://dlib.phenikaa-uni.edu.vn/handle/PNK/8196 |
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oai:localhost:PNK-81962023-04-21T03:48:48Z Design, synthesis and antitumor activity of new naproxen based 1,2,4-triazole-Schiff base derivatives Nawaf I., Alsenani new Naproxen synthesis and antitumor activity CC BY In the present work, new Naproxen based 1,2,4-triazole-Schiff base derivatives have been synthesized and screened for in vitro antitumor activity and in silico pharmacokinetic studies. The structure of the newly synthesized compounds (5–12) was elucidated by IR, NMR and mass spectrometry. All the compounds were tested against breast MCF-7, hepatocellular Huh-7 and lung A-549 cancer cell lines using MTT assay. Compound 7 was better in killing A549 cells with IC50 3.71 µM (1.48 fold), compared with Doxorubicin (IC50 5.50 µM). Also, compound 7 was found to be non toxic on MRC-5 normal cells as it depicts IC50 more than 500 μM. Besides, compound 12 also revealed promising activity with IC50 6.94 and 3.33 µM against MCF-7 and Huh-7 respectively. 2023-04-21T03:48:47Z 2023-04-21T03:48:47Z 2023 Book https://link.springer.com/article/10.1007/s43994-023-00044-7 https://dlib.phenikaa-uni.edu.vn/handle/PNK/8196 en application/pdf Springer |
| institution |
Digital Phenikaa |
| collection |
Digital Phenikaa |
| language |
English |
| topic |
new Naproxen synthesis and antitumor activity |
| spellingShingle |
new Naproxen synthesis and antitumor activity Nawaf I., Alsenani Design, synthesis and antitumor activity of new naproxen based 1,2,4-triazole-Schiff base derivatives |
| description |
CC BY |
| format |
Book |
| author |
Nawaf I., Alsenani |
| author_facet |
Nawaf I., Alsenani |
| author_sort |
Nawaf I., Alsenani |
| title |
Design, synthesis and antitumor activity of new naproxen based 1,2,4-triazole-Schiff base derivatives |
| title_short |
Design, synthesis and antitumor activity of new naproxen based 1,2,4-triazole-Schiff base derivatives |
| title_full |
Design, synthesis and antitumor activity of new naproxen based 1,2,4-triazole-Schiff base derivatives |
| title_fullStr |
Design, synthesis and antitumor activity of new naproxen based 1,2,4-triazole-Schiff base derivatives |
| title_full_unstemmed |
Design, synthesis and antitumor activity of new naproxen based 1,2,4-triazole-Schiff base derivatives |
| title_sort |
design, synthesis and antitumor activity of new naproxen based 1,2,4-triazole-schiff base derivatives |
| publisher |
Springer |
| publishDate |
2023 |
| url |
https://link.springer.com/article/10.1007/s43994-023-00044-7 https://dlib.phenikaa-uni.edu.vn/handle/PNK/8196 |
| _version_ |
1763815059080871936 |
| score |
8.887836 |