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Design, synthesis and antitumor activity of new naproxen based 1,2,4-triazole-Schiff base derivatives

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Bibliographic Details
Main Author: Nawaf I., Alsenani
Format: Book
Language:English
Published: Springer 2023
Subjects:
new Naproxen
synthesis and antitumor activity
Online Access:https://link.springer.com/article/10.1007/s43994-023-00044-7
https://dlib.phenikaa-uni.edu.vn/handle/PNK/8196
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spelling oai:localhost:PNK-81962023-04-21T03:48:48Z Design, synthesis and antitumor activity of new naproxen based 1,2,4-triazole-Schiff base derivatives Nawaf I., Alsenani new Naproxen synthesis and antitumor activity CC BY In the present work, new Naproxen based 1,2,4-triazole-Schiff base derivatives have been synthesized and screened for in vitro antitumor activity and in silico pharmacokinetic studies. The structure of the newly synthesized compounds (5–12) was elucidated by IR, NMR and mass spectrometry. All the compounds were tested against breast MCF-7, hepatocellular Huh-7 and lung A-549 cancer cell lines using MTT assay. Compound 7 was better in killing A549 cells with IC50 3.71 µM (1.48 fold), compared with Doxorubicin (IC50 5.50 µM). Also, compound 7 was found to be non toxic on MRC-5 normal cells as it depicts IC50 more than 500 μM. Besides, compound 12 also revealed promising activity with IC50 6.94 and 3.33 µM against MCF-7 and Huh-7 respectively. 2023-04-21T03:48:47Z 2023-04-21T03:48:47Z 2023 Book https://link.springer.com/article/10.1007/s43994-023-00044-7 https://dlib.phenikaa-uni.edu.vn/handle/PNK/8196 en application/pdf Springer
institution Digital Phenikaa
collection Digital Phenikaa
language English
topic new Naproxen
synthesis and antitumor activity
spellingShingle new Naproxen
synthesis and antitumor activity
Nawaf I., Alsenani
Design, synthesis and antitumor activity of new naproxen based 1,2,4-triazole-Schiff base derivatives
description CC BY
format Book
author Nawaf I., Alsenani
author_facet Nawaf I., Alsenani
author_sort Nawaf I., Alsenani
title Design, synthesis and antitumor activity of new naproxen based 1,2,4-triazole-Schiff base derivatives
title_short Design, synthesis and antitumor activity of new naproxen based 1,2,4-triazole-Schiff base derivatives
title_full Design, synthesis and antitumor activity of new naproxen based 1,2,4-triazole-Schiff base derivatives
title_fullStr Design, synthesis and antitumor activity of new naproxen based 1,2,4-triazole-Schiff base derivatives
title_full_unstemmed Design, synthesis and antitumor activity of new naproxen based 1,2,4-triazole-Schiff base derivatives
title_sort design, synthesis and antitumor activity of new naproxen based 1,2,4-triazole-schiff base derivatives
publisher Springer
publishDate 2023
url https://link.springer.com/article/10.1007/s43994-023-00044-7
https://dlib.phenikaa-uni.edu.vn/handle/PNK/8196
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score 8.891787

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