Circular RNA COL1A2 Mediates High Glucose-Induced Oxidative Stress and Pyroptosis by Regulating MiR-424-5p/SGK1 in Diabetic Nephropathy
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| Định dạng: | Sách |
| Ngôn ngữ: | English |
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Springer
2023
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| Truy cập trực tuyến: | https://link.springer.com/article/10.1007/s12010-023-04501-1 https://dlib.phenikaa-uni.edu.vn/handle/PNK/8180 |
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oai:localhost:PNK-81802023-04-21T01:31:42Z Circular RNA COL1A2 Mediates High Glucose-Induced Oxidative Stress and Pyroptosis by Regulating MiR-424-5p/SGK1 in Diabetic Nephropathy Langen, Zhuang Guoxi, Jin Wang, qiong DN CircCOL1A2 CC BY Diabetic nephropathy (DN) represents a major diabetes-related complication, which could undermine renal function. CircCOL1A2 has been previously reported to show abnormal expression during DN. However, its functional role in the progression of DN, as well as the potential molecular mechanisms, remains unclear. The present work examined the expression of circCOL1A2 in the plasma of DN patients, and employed high glucose (HG)-challenged HK-2 cells as the in vitro cell model of hyperglycemia (HG)-induced DN. CircCOL1A2 was silenced using siRNA in HK-2 cells to clarify the functional engagement of circCOL1A2 in HG-induced DN. We examined the roles of circCOL1A2 in regulating oxidative stress by measuring reactive oxygen species (ROS), lipid peroxidation, and superoxide dismutase (SOD) levels. 2023-04-21T01:31:42Z 2023-04-21T01:31:42Z 2023 Book https://link.springer.com/article/10.1007/s12010-023-04501-1 https://dlib.phenikaa-uni.edu.vn/handle/PNK/8180 en application/pdf Springer |
| institution |
Digital Phenikaa |
| collection |
Digital Phenikaa |
| language |
English |
| topic |
DN CircCOL1A2 |
| spellingShingle |
DN CircCOL1A2 Langen, Zhuang Guoxi, Jin Wang, qiong Circular RNA COL1A2 Mediates High Glucose-Induced Oxidative Stress and Pyroptosis by Regulating MiR-424-5p/SGK1 in Diabetic Nephropathy |
| description |
CC BY |
| format |
Book |
| author |
Langen, Zhuang Guoxi, Jin Wang, qiong |
| author_facet |
Langen, Zhuang Guoxi, Jin Wang, qiong |
| author_sort |
Langen, Zhuang |
| title |
Circular RNA COL1A2 Mediates High Glucose-Induced Oxidative Stress and Pyroptosis by Regulating MiR-424-5p/SGK1 in Diabetic Nephropathy |
| title_short |
Circular RNA COL1A2 Mediates High Glucose-Induced Oxidative Stress and Pyroptosis by Regulating MiR-424-5p/SGK1 in Diabetic Nephropathy |
| title_full |
Circular RNA COL1A2 Mediates High Glucose-Induced Oxidative Stress and Pyroptosis by Regulating MiR-424-5p/SGK1 in Diabetic Nephropathy |
| title_fullStr |
Circular RNA COL1A2 Mediates High Glucose-Induced Oxidative Stress and Pyroptosis by Regulating MiR-424-5p/SGK1 in Diabetic Nephropathy |
| title_full_unstemmed |
Circular RNA COL1A2 Mediates High Glucose-Induced Oxidative Stress and Pyroptosis by Regulating MiR-424-5p/SGK1 in Diabetic Nephropathy |
| title_sort |
circular rna col1a2 mediates high glucose-induced oxidative stress and pyroptosis by regulating mir-424-5p/sgk1 in diabetic nephropathy |
| publisher |
Springer |
| publishDate |
2023 |
| url |
https://link.springer.com/article/10.1007/s12010-023-04501-1 https://dlib.phenikaa-uni.edu.vn/handle/PNK/8180 |
| _version_ |
1763815057867669504 |
| score |
8.881002 |