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Circular RNA COL1A2 Mediates High Glucose-Induced Oxidative Stress and Pyroptosis by Regulating MiR-424-5p/SGK1 in Diabetic Nephropathy

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Bibliographic Details
Main Authors: Langen, Zhuang, Guoxi, Jin, Wang, qiong
Format: Book
Language:English
Published: Springer 2023
Subjects:
DN
CircCOL1A2
Online Access:https://link.springer.com/article/10.1007/s12010-023-04501-1
https://dlib.phenikaa-uni.edu.vn/handle/PNK/8180
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spelling oai:localhost:PNK-81802023-04-21T01:31:42Z Circular RNA COL1A2 Mediates High Glucose-Induced Oxidative Stress and Pyroptosis by Regulating MiR-424-5p/SGK1 in Diabetic Nephropathy Langen, Zhuang Guoxi, Jin Wang, qiong DN CircCOL1A2 CC BY Diabetic nephropathy (DN) represents a major diabetes-related complication, which could undermine renal function. CircCOL1A2 has been previously reported to show abnormal expression during DN. However, its functional role in the progression of DN, as well as the potential molecular mechanisms, remains unclear. The present work examined the expression of circCOL1A2 in the plasma of DN patients, and employed high glucose (HG)-challenged HK-2 cells as the in vitro cell model of hyperglycemia (HG)-induced DN. CircCOL1A2 was silenced using siRNA in HK-2 cells to clarify the functional engagement of circCOL1A2 in HG-induced DN. We examined the roles of circCOL1A2 in regulating oxidative stress by measuring reactive oxygen species (ROS), lipid peroxidation, and superoxide dismutase (SOD) levels. 2023-04-21T01:31:42Z 2023-04-21T01:31:42Z 2023 Book https://link.springer.com/article/10.1007/s12010-023-04501-1 https://dlib.phenikaa-uni.edu.vn/handle/PNK/8180 en application/pdf Springer
institution Digital Phenikaa
collection Digital Phenikaa
language English
topic DN
CircCOL1A2
spellingShingle DN
CircCOL1A2
Langen, Zhuang
Guoxi, Jin
Wang, qiong
Circular RNA COL1A2 Mediates High Glucose-Induced Oxidative Stress and Pyroptosis by Regulating MiR-424-5p/SGK1 in Diabetic Nephropathy
description CC BY
format Book
author Langen, Zhuang
Guoxi, Jin
Wang, qiong
author_facet Langen, Zhuang
Guoxi, Jin
Wang, qiong
author_sort Langen, Zhuang
title Circular RNA COL1A2 Mediates High Glucose-Induced Oxidative Stress and Pyroptosis by Regulating MiR-424-5p/SGK1 in Diabetic Nephropathy
title_short Circular RNA COL1A2 Mediates High Glucose-Induced Oxidative Stress and Pyroptosis by Regulating MiR-424-5p/SGK1 in Diabetic Nephropathy
title_full Circular RNA COL1A2 Mediates High Glucose-Induced Oxidative Stress and Pyroptosis by Regulating MiR-424-5p/SGK1 in Diabetic Nephropathy
title_fullStr Circular RNA COL1A2 Mediates High Glucose-Induced Oxidative Stress and Pyroptosis by Regulating MiR-424-5p/SGK1 in Diabetic Nephropathy
title_full_unstemmed Circular RNA COL1A2 Mediates High Glucose-Induced Oxidative Stress and Pyroptosis by Regulating MiR-424-5p/SGK1 in Diabetic Nephropathy
title_sort circular rna col1a2 mediates high glucose-induced oxidative stress and pyroptosis by regulating mir-424-5p/sgk1 in diabetic nephropathy
publisher Springer
publishDate 2023
url https://link.springer.com/article/10.1007/s12010-023-04501-1
https://dlib.phenikaa-uni.edu.vn/handle/PNK/8180
_version_ 1763815057867669504
score 8.881002

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