Rapid emergence from dexmedetomidine sedation in Sprague Dawley rats by repurposing an α2-adrenergic receptor competitive antagonist in combination with caffeine
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| Định dạng: | Sách |
| Ngôn ngữ: | English |
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Springer
2023
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| Truy cập trực tuyến: | https://link.springer.com/article/10.1186/s12871-023-01986-5 https://dlib.phenikaa-uni.edu.vn/handle/PNK/7180 |
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oai:localhost:PNK-71802023-03-27T07:45:11Z Rapid emergence from dexmedetomidine sedation in Sprague Dawley rats by repurposing an α2-adrenergic receptor competitive antagonist in combination with caffeine Zheng, Xie Aaron P., Fox α2 adrenergic receptor agonist dexmedetomidine analgesic properties CC BY The α2 adrenergic receptor agonist dexmedetomidine is an important intravenous sedative with analgesic properties. Currently available dexmedetomidine reversal agents, like the α2-receptor antagonist atipamezole, cause serious adverse effects at the large dosages required for effective reversal; they are not used clinically. Without reversal agents, emergence times from dexmedetomidine sedation are slow. In this study we tested the ability of low-dose atipamezole, in combination with caffeine, to reverse dexmedetomidine sedation. The low dose of atipamezole employed should not be associated with unwanted effects. 2023-03-27T07:45:09Z 2023-03-27T07:45:09Z 2023 Book https://link.springer.com/article/10.1186/s12871-023-01986-5 https://dlib.phenikaa-uni.edu.vn/handle/PNK/7180 en application/pdf Springer |
| institution |
Digital Phenikaa |
| collection |
Digital Phenikaa |
| language |
English |
| topic |
α2 adrenergic receptor agonist dexmedetomidine analgesic properties |
| spellingShingle |
α2 adrenergic receptor agonist dexmedetomidine analgesic properties Zheng, Xie Aaron P., Fox Rapid emergence from dexmedetomidine sedation in Sprague Dawley rats by repurposing an α2-adrenergic receptor competitive antagonist in combination with caffeine |
| description |
CC BY |
| format |
Book |
| author |
Zheng, Xie Aaron P., Fox |
| author_facet |
Zheng, Xie Aaron P., Fox |
| author_sort |
Zheng, Xie |
| title |
Rapid emergence from dexmedetomidine sedation in Sprague Dawley rats by repurposing an α2-adrenergic receptor competitive antagonist in combination with caffeine |
| title_short |
Rapid emergence from dexmedetomidine sedation in Sprague Dawley rats by repurposing an α2-adrenergic receptor competitive antagonist in combination with caffeine |
| title_full |
Rapid emergence from dexmedetomidine sedation in Sprague Dawley rats by repurposing an α2-adrenergic receptor competitive antagonist in combination with caffeine |
| title_fullStr |
Rapid emergence from dexmedetomidine sedation in Sprague Dawley rats by repurposing an α2-adrenergic receptor competitive antagonist in combination with caffeine |
| title_full_unstemmed |
Rapid emergence from dexmedetomidine sedation in Sprague Dawley rats by repurposing an α2-adrenergic receptor competitive antagonist in combination with caffeine |
| title_sort |
rapid emergence from dexmedetomidine sedation in sprague dawley rats by repurposing an α2-adrenergic receptor competitive antagonist in combination with caffeine |
| publisher |
Springer |
| publishDate |
2023 |
| url |
https://link.springer.com/article/10.1186/s12871-023-01986-5 https://dlib.phenikaa-uni.edu.vn/handle/PNK/7180 |
| _version_ |
1761550127102689280 |
| score |
8.881002 |