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Rapid emergence from dexmedetomidine sedation in Sprague Dawley rats by repurposing an α2-adrenergic receptor competitive antagonist in combination with caffeine

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Bibliographic Details
Main Authors: Zheng, Xie, Aaron P., Fox
Format: Book
Language:English
Published: Springer 2023
Subjects:
α2 adrenergic receptor agonist dexmedetomidine
analgesic properties
Online Access:https://link.springer.com/article/10.1186/s12871-023-01986-5
https://dlib.phenikaa-uni.edu.vn/handle/PNK/7180
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spelling oai:localhost:PNK-71802023-03-27T07:45:11Z Rapid emergence from dexmedetomidine sedation in Sprague Dawley rats by repurposing an α2-adrenergic receptor competitive antagonist in combination with caffeine Zheng, Xie Aaron P., Fox α2 adrenergic receptor agonist dexmedetomidine analgesic properties CC BY The α2 adrenergic receptor agonist dexmedetomidine is an important intravenous sedative with analgesic properties. Currently available dexmedetomidine reversal agents, like the α2-receptor antagonist atipamezole, cause serious adverse effects at the large dosages required for effective reversal; they are not used clinically. Without reversal agents, emergence times from dexmedetomidine sedation are slow. In this study we tested the ability of low-dose atipamezole, in combination with caffeine, to reverse dexmedetomidine sedation. The low dose of atipamezole employed should not be associated with unwanted effects. 2023-03-27T07:45:09Z 2023-03-27T07:45:09Z 2023 Book https://link.springer.com/article/10.1186/s12871-023-01986-5 https://dlib.phenikaa-uni.edu.vn/handle/PNK/7180 en application/pdf Springer
institution Digital Phenikaa
collection Digital Phenikaa
language English
topic α2 adrenergic receptor agonist dexmedetomidine
analgesic properties
spellingShingle α2 adrenergic receptor agonist dexmedetomidine
analgesic properties
Zheng, Xie
Aaron P., Fox
Rapid emergence from dexmedetomidine sedation in Sprague Dawley rats by repurposing an α2-adrenergic receptor competitive antagonist in combination with caffeine
description CC BY
format Book
author Zheng, Xie
Aaron P., Fox
author_facet Zheng, Xie
Aaron P., Fox
author_sort Zheng, Xie
title Rapid emergence from dexmedetomidine sedation in Sprague Dawley rats by repurposing an α2-adrenergic receptor competitive antagonist in combination with caffeine
title_short Rapid emergence from dexmedetomidine sedation in Sprague Dawley rats by repurposing an α2-adrenergic receptor competitive antagonist in combination with caffeine
title_full Rapid emergence from dexmedetomidine sedation in Sprague Dawley rats by repurposing an α2-adrenergic receptor competitive antagonist in combination with caffeine
title_fullStr Rapid emergence from dexmedetomidine sedation in Sprague Dawley rats by repurposing an α2-adrenergic receptor competitive antagonist in combination with caffeine
title_full_unstemmed Rapid emergence from dexmedetomidine sedation in Sprague Dawley rats by repurposing an α2-adrenergic receptor competitive antagonist in combination with caffeine
title_sort rapid emergence from dexmedetomidine sedation in sprague dawley rats by repurposing an α2-adrenergic receptor competitive antagonist in combination with caffeine
publisher Springer
publishDate 2023
url https://link.springer.com/article/10.1186/s12871-023-01986-5
https://dlib.phenikaa-uni.edu.vn/handle/PNK/7180
_version_ 1761550127102689280
score 8.881002

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