Elevated free interleukin-18 associated with severity and mortality in prospective cohort study of 206 hospitalised COVID-19 patients
Divergence between deterioration to life-threatening COVID-19 or clinical improvement occurs for most within the first 14 days of symptoms. Life-threatening COVID-19 shares clinical similarities with Macrophage Activation Syndrome, which can be driven by elevated Free Interleukin-18 (IL-18) due to f...
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| Định dạng: | Sách |
| Ngôn ngữ: | English |
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Springer
2023
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| Truy cập trực tuyến: | https://link.springer.com/article/10.1186/s40635-022-00488-x https://dlib.phenikaa-uni.edu.vn/handle/PNK/7012 |
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oai:localhost:PNK-70122023-03-21T03:05:17Z Elevated free interleukin-18 associated with severity and mortality in prospective cohort study of 206 hospitalised COVID-19 patients Syed M. T., Nasser Anas A., Rana Rainer, Doffinger free interleukin-18 constant (Kd) of 0.05 nmol Divergence between deterioration to life-threatening COVID-19 or clinical improvement occurs for most within the first 14 days of symptoms. Life-threatening COVID-19 shares clinical similarities with Macrophage Activation Syndrome, which can be driven by elevated Free Interleukin-18 (IL-18) due to failure of negative-feedback release of IL-18 binding protein (IL-18bp). We, therefore, designed a prospective, longitudinal cohort study to examine IL-18 negative-feedback control in relation to COVID-19 severity and mortality from symptom day 15 onwards. 2023-03-21T03:05:17Z 2023-03-21T03:05:17Z 2023 Book https://link.springer.com/article/10.1186/s40635-022-00488-x https://dlib.phenikaa-uni.edu.vn/handle/PNK/7012 en application/pdf Springer |
| institution |
Digital Phenikaa |
| collection |
Digital Phenikaa |
| language |
English |
| topic |
free interleukin-18 constant (Kd) of 0.05 nmol |
| spellingShingle |
free interleukin-18 constant (Kd) of 0.05 nmol Syed M. T., Nasser Anas A., Rana Rainer, Doffinger Elevated free interleukin-18 associated with severity and mortality in prospective cohort study of 206 hospitalised COVID-19 patients |
| description |
Divergence between deterioration to life-threatening COVID-19 or clinical improvement occurs for most within the first 14 days of symptoms. Life-threatening COVID-19 shares clinical similarities with Macrophage Activation Syndrome, which can be driven by elevated Free Interleukin-18 (IL-18) due to failure of negative-feedback release of IL-18 binding protein (IL-18bp). We, therefore, designed a prospective, longitudinal cohort study to examine IL-18 negative-feedback control in relation to COVID-19 severity and mortality from symptom day 15 onwards. |
| format |
Book |
| author |
Syed M. T., Nasser Anas A., Rana Rainer, Doffinger |
| author_facet |
Syed M. T., Nasser Anas A., Rana Rainer, Doffinger |
| author_sort |
Syed M. T., Nasser |
| title |
Elevated free interleukin-18 associated with severity and mortality in prospective cohort study of 206 hospitalised COVID-19 patients |
| title_short |
Elevated free interleukin-18 associated with severity and mortality in prospective cohort study of 206 hospitalised COVID-19 patients |
| title_full |
Elevated free interleukin-18 associated with severity and mortality in prospective cohort study of 206 hospitalised COVID-19 patients |
| title_fullStr |
Elevated free interleukin-18 associated with severity and mortality in prospective cohort study of 206 hospitalised COVID-19 patients |
| title_full_unstemmed |
Elevated free interleukin-18 associated with severity and mortality in prospective cohort study of 206 hospitalised COVID-19 patients |
| title_sort |
elevated free interleukin-18 associated with severity and mortality in prospective cohort study of 206 hospitalised covid-19 patients |
| publisher |
Springer |
| publishDate |
2023 |
| url |
https://link.springer.com/article/10.1186/s40635-022-00488-x https://dlib.phenikaa-uni.edu.vn/handle/PNK/7012 |
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1761006543132688384 |
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8.887836 |