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Elevated free interleukin-18 associated with severity and mortality in prospective cohort study of 206 hospitalised COVID-19 patients

Divergence between deterioration to life-threatening COVID-19 or clinical improvement occurs for most within the first 14 days of symptoms. Life-threatening COVID-19 shares clinical similarities with Macrophage Activation Syndrome, which can be driven by elevated Free Interleukin-18 (IL-18) due to f...

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Bibliographic Details
Main Authors: Syed M. T., Nasser, Anas A., Rana, Rainer, Doffinger
Format: Book
Language:English
Published: Springer 2023
Subjects:
free interleukin-18
constant (Kd) of 0.05 nmol
Online Access:https://link.springer.com/article/10.1186/s40635-022-00488-x
https://dlib.phenikaa-uni.edu.vn/handle/PNK/7012
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spelling oai:localhost:PNK-70122023-03-21T03:05:17Z Elevated free interleukin-18 associated with severity and mortality in prospective cohort study of 206 hospitalised COVID-19 patients Syed M. T., Nasser Anas A., Rana Rainer, Doffinger free interleukin-18 constant (Kd) of 0.05 nmol Divergence between deterioration to life-threatening COVID-19 or clinical improvement occurs for most within the first 14 days of symptoms. Life-threatening COVID-19 shares clinical similarities with Macrophage Activation Syndrome, which can be driven by elevated Free Interleukin-18 (IL-18) due to failure of negative-feedback release of IL-18 binding protein (IL-18bp). We, therefore, designed a prospective, longitudinal cohort study to examine IL-18 negative-feedback control in relation to COVID-19 severity and mortality from symptom day 15 onwards. 2023-03-21T03:05:17Z 2023-03-21T03:05:17Z 2023 Book https://link.springer.com/article/10.1186/s40635-022-00488-x https://dlib.phenikaa-uni.edu.vn/handle/PNK/7012 en application/pdf Springer
institution Digital Phenikaa
collection Digital Phenikaa
language English
topic free interleukin-18
constant (Kd) of 0.05 nmol
spellingShingle free interleukin-18
constant (Kd) of 0.05 nmol
Syed M. T., Nasser
Anas A., Rana
Rainer, Doffinger
Elevated free interleukin-18 associated with severity and mortality in prospective cohort study of 206 hospitalised COVID-19 patients
description Divergence between deterioration to life-threatening COVID-19 or clinical improvement occurs for most within the first 14 days of symptoms. Life-threatening COVID-19 shares clinical similarities with Macrophage Activation Syndrome, which can be driven by elevated Free Interleukin-18 (IL-18) due to failure of negative-feedback release of IL-18 binding protein (IL-18bp). We, therefore, designed a prospective, longitudinal cohort study to examine IL-18 negative-feedback control in relation to COVID-19 severity and mortality from symptom day 15 onwards.
format Book
author Syed M. T., Nasser
Anas A., Rana
Rainer, Doffinger
author_facet Syed M. T., Nasser
Anas A., Rana
Rainer, Doffinger
author_sort Syed M. T., Nasser
title Elevated free interleukin-18 associated with severity and mortality in prospective cohort study of 206 hospitalised COVID-19 patients
title_short Elevated free interleukin-18 associated with severity and mortality in prospective cohort study of 206 hospitalised COVID-19 patients
title_full Elevated free interleukin-18 associated with severity and mortality in prospective cohort study of 206 hospitalised COVID-19 patients
title_fullStr Elevated free interleukin-18 associated with severity and mortality in prospective cohort study of 206 hospitalised COVID-19 patients
title_full_unstemmed Elevated free interleukin-18 associated with severity and mortality in prospective cohort study of 206 hospitalised COVID-19 patients
title_sort elevated free interleukin-18 associated with severity and mortality in prospective cohort study of 206 hospitalised covid-19 patients
publisher Springer
publishDate 2023
url https://link.springer.com/article/10.1186/s40635-022-00488-x
https://dlib.phenikaa-uni.edu.vn/handle/PNK/7012
_version_ 1761006543132688384
score 8.88091

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