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Targeting circulating high mobility group box-1 and histones by extracorporeal blood purification as an immunomodulation strategy against critical illnesses

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Bibliographic Details
Main Authors: Yupei, Li, Yu, Chen, Tinghang, Yang
Format: Book
Language:English
Published: Springer 2023
Subjects:
high mobility group box-1
damage-associated molecular patterns
Online Access:https://link.springer.com/article/10.1186/s13054-023-04382-0
https://dlib.phenikaa-uni.edu.vn/handle/PNK/6995
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spelling oai:localhost:PNK-69952023-03-20T08:24:56Z Targeting circulating high mobility group box-1 and histones by extracorporeal blood purification as an immunomodulation strategy against critical illnesses Yupei, Li Yu, Chen Tinghang, Yang high mobility group box-1 damage-associated molecular patterns CC BY Both high mobility group box-1 (HMGB1) and histones are major damage-associated molecular patterns (DAPMs) that mediate lethal systemic inflammation, activation of the complement and coagulation system, endothelial injury and multiple organ dysfunction syndrome in critical illnesses. Although accumulating evidence collectively shows that targeting HMGB1 or histones by their specific antibodies or inhibitors could significantly mitigate aberrant immune responses in multiple critically ill animal models, routine clinical use of such agents is still not recommended by any guideline. 2023-03-20T08:24:56Z 2023-03-20T08:24:56Z 2023 Book https://link.springer.com/article/10.1186/s13054-023-04382-0 https://dlib.phenikaa-uni.edu.vn/handle/PNK/6995 en application/pdf Springer
institution Digital Phenikaa
collection Digital Phenikaa
language English
topic high mobility group box-1
damage-associated molecular patterns
spellingShingle high mobility group box-1
damage-associated molecular patterns
Yupei, Li
Yu, Chen
Tinghang, Yang
Targeting circulating high mobility group box-1 and histones by extracorporeal blood purification as an immunomodulation strategy against critical illnesses
description CC BY
format Book
author Yupei, Li
Yu, Chen
Tinghang, Yang
author_facet Yupei, Li
Yu, Chen
Tinghang, Yang
author_sort Yupei, Li
title Targeting circulating high mobility group box-1 and histones by extracorporeal blood purification as an immunomodulation strategy against critical illnesses
title_short Targeting circulating high mobility group box-1 and histones by extracorporeal blood purification as an immunomodulation strategy against critical illnesses
title_full Targeting circulating high mobility group box-1 and histones by extracorporeal blood purification as an immunomodulation strategy against critical illnesses
title_fullStr Targeting circulating high mobility group box-1 and histones by extracorporeal blood purification as an immunomodulation strategy against critical illnesses
title_full_unstemmed Targeting circulating high mobility group box-1 and histones by extracorporeal blood purification as an immunomodulation strategy against critical illnesses
title_sort targeting circulating high mobility group box-1 and histones by extracorporeal blood purification as an immunomodulation strategy against critical illnesses
publisher Springer
publishDate 2023
url https://link.springer.com/article/10.1186/s13054-023-04382-0
https://dlib.phenikaa-uni.edu.vn/handle/PNK/6995
_version_ 1760915945952378880
score 8.891053

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