Network pharmacology-based mechanism prediction and pharmacological validation of Bushenhuoxue formula attenuating postmenopausal osteoporosis in ovariectomized mice
Postmenopausal osteoporosis (PMOP) is a common bone disorder characterized by low bone mineral density and microstructure deterioration [1]. It is estimated that more than 15% of postmenopausal women over 50 years old are suffering in PMOP worldwide [2]. Most of them have low back pain, hunchback an...
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| Main Authors: | , , , |
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| Format: | Book |
| Language: | English |
| Published: |
Springer
2023
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| Subjects: | |
| Online Access: | https://link.springer.com/article/10.1186/s13018-023-03696-7 https://dlib.phenikaa-uni.edu.vn/handle/PNK/6765 |
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| Summary: | Postmenopausal osteoporosis (PMOP) is a common bone disorder characterized by low bone mineral density and microstructure deterioration [1]. It is estimated that more than 15% of postmenopausal women over 50 years old are suffering in PMOP worldwide [2]. Most of them have low back pain, hunchback and fragility fractures in different degrees [3]. Although there exist a large amount of anti-osteoporosis drugs such as active vitamin D, estrogen receptor modulators, bisphosphonates and parathyroid hormone [4], various undesirable effects limit their application and efficacy [5]. Natural products and herbs attract increasing attention for their potential anti-osteoporosis effects and relative safety |
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