Design, Synthesis and Evaluation of Novel (E)-N'-((1-(4-chlorobenzyl)-1H-indol-3-yl)methylene)-2-(4-oxoquinazolin-3(4H)-yl)acetohydrazides as Antitumor Agents

A biological evaluation revealed that all thirteen compounds designed and synthesized showed strong cytotoxicity against three human cancer cell lines (SW620, colon cancer; PC-3, prostate cancer; NCI-H23, lung cancer) with eight compounds (5a, 5c-i, 5k), which were clearly more potent than both PAC-...

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Bibliographic Details
Main Authors: Do, Thi Mai Dung, Eun, Jae Park, Duong, Tien Anh
Format: Bài trích
Language:English
Published: Bentham Science Publishers 2022
Subjects:
Online Access:https://www.eurekaselect.com/article/120263
https://dlib.phenikaa-uni.edu.vn/handle/PNK/5864
https://doi.org/10.2174/1871520622666220118154914
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