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Stabilization of Single Turn Polyproline II Helices via Macrocyclic Hydrocarbon Staples

Polyproline II helix (PPII) is one of the secondary structures in proteins that play an important role in various biological processes. In this study, we have developed a new macrocyclization strategy that efficiently reinforces a model tetrapeptide into a PPII structure. We also elucidated some rel...

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Main Authors: Huy X. Luong, Young-Woo Kim
Format: Article
Language:English
Published: ACS Publications 2020
Subjects:
Peptides and proteins
Circular dichroism spectroscopy,
Chemical structure
Metathesis
Nucleic acid structure
Online Access:https://pubs.acs.org/doi/10.1021/acs.orglett.0c02914
https://dlib.phenikaa-uni.edu.vn/handle/PNK/586
https://doi.org/10.1021/acs.orglett.0c02914
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spelling oai:localhost:PNK-5862022-08-17T05:54:38Z Stabilization of Single Turn Polyproline II Helices via Macrocyclic Hydrocarbon Staples Huy X. Luong Young-Woo Kim Peptides and proteins Circular dichroism spectroscopy, Chemical structure Metathesis Nucleic acid structure Polyproline II helix (PPII) is one of the secondary structures in proteins that play an important role in various biological processes. In this study, we have developed a new macrocyclization strategy that efficiently reinforces a model tetrapeptide into a PPII structure. We also elucidated some relationships between structural features and PPII stability in this model. This new macrocyclic stapling strategy can serve as a useful chemical tool to manipulate the PPII structure for various applications. 2020-10-13T04:18:12Z 2020-10-13T04:18:12Z 2020 Article Working Paper https://pubs.acs.org/doi/10.1021/acs.orglett.0c02914 https://dlib.phenikaa-uni.edu.vn/handle/PNK/586 https://doi.org/10.1021/acs.orglett.0c02914 en application/pdf ACS Publications
institution Digital Phenikaa
collection Digital Phenikaa
language English
topic Peptides and proteins
Circular dichroism spectroscopy,
Chemical structure
Metathesis
Nucleic acid structure
spellingShingle Peptides and proteins
Circular dichroism spectroscopy,
Chemical structure
Metathesis
Nucleic acid structure
Huy X. Luong
Young-Woo Kim
Stabilization of Single Turn Polyproline II Helices via Macrocyclic Hydrocarbon Staples
description Polyproline II helix (PPII) is one of the secondary structures in proteins that play an important role in various biological processes. In this study, we have developed a new macrocyclization strategy that efficiently reinforces a model tetrapeptide into a PPII structure. We also elucidated some relationships between structural features and PPII stability in this model. This new macrocyclic stapling strategy can serve as a useful chemical tool to manipulate the PPII structure for various applications.
format Article
author Huy X. Luong
Young-Woo Kim
author_facet Huy X. Luong
Young-Woo Kim
author_sort Huy X. Luong
title Stabilization of Single Turn Polyproline II Helices via Macrocyclic Hydrocarbon Staples
title_short Stabilization of Single Turn Polyproline II Helices via Macrocyclic Hydrocarbon Staples
title_full Stabilization of Single Turn Polyproline II Helices via Macrocyclic Hydrocarbon Staples
title_fullStr Stabilization of Single Turn Polyproline II Helices via Macrocyclic Hydrocarbon Staples
title_full_unstemmed Stabilization of Single Turn Polyproline II Helices via Macrocyclic Hydrocarbon Staples
title_sort stabilization of single turn polyproline ii helices via macrocyclic hydrocarbon staples
publisher ACS Publications
publishDate 2020
url https://pubs.acs.org/doi/10.1021/acs.orglett.0c02914
https://dlib.phenikaa-uni.edu.vn/handle/PNK/586
https://doi.org/10.1021/acs.orglett.0c02914
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score 8.891787

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