Hiển thị ở chế độ nhân viên: Adenovirus-α-Defensin Complexes Induce NLRP3-Associated Maturation of Human Phagocytes via Toll-Like Receptor 4 Engagement

Adenovirus-α-Defensin Complexes Induce NLRP3-Associated Maturation of Human Phagocytes via Toll-Like Receptor 4 Engagement

Intramuscular delivery of human adenovirus (HAdV)-based vaccines leads to rapid recruitment of neutrophils, which then release antimicrobial peptides/proteins (AMPs). How these AMPs influence vaccine efficacy over the subsequent 24 h is poorly understood. In this study, we asked if human neutrophil...

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Tác giả chính:	Karsten, Eichholz, Tuan, Hiep Tran, Coraline ,Chéneau, Tran, Thi Thu Phuong, Océane, Paris, Martine, Pugniere, Eric, J. Kremer
Định dạng:	Bài trích
Ngôn ngữ:	English
Nhà xuất bản:	American Society for Microbiology 2022
Chủ đề:	Adenovirus-α-Defensin NLRP3-Associated
Truy cập trực tuyến:	https://journals.asm.org/doi/10.1128/jvi.01850-21 https://dlib.phenikaa-uni.edu.vn/handle/PNK/5735 https://doi.org/10.1128/jvi.01850-21
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spelling	oai:localhost:PNK-57352022-08-17T05:54:52Z Adenovirus-α-Defensin Complexes Induce NLRP3-Associated Maturation of Human Phagocytes via Toll-Like Receptor 4 Engagement Karsten, Eichholz Tuan, Hiep Tran Coraline ,Chéneau Tran, Thi Thu Phuong Océane, Paris Martine, Pugniere Eric, J. Kremer Adenovirus-α-Defensin NLRP3-Associated Intramuscular delivery of human adenovirus (HAdV)-based vaccines leads to rapid recruitment of neutrophils, which then release antimicrobial peptides/proteins (AMPs). How these AMPs influence vaccine efficacy over the subsequent 24 h is poorly understood. In this study, we asked if human neutrophil protein 1 (HNP-1), an α-defensin that influences direct and indirect innate immune responses to a range of pathogens, impacts the response of human phagocytes to three HAdV species/types (HAdV-C5, -D26, -B35). We show that HNP-1 binds to the capsids and redirects HAdV-C5, -D26, and -B35 to Toll-like receptor 4 (TLR4), which leads to internalization, an NLRP3-mediated inflammasome response, and interleukin 1 beta (IL-1β) release. Surprisingly, IL-1β release was not associated with notable disruption of plasma membrane integrity. These data further our understanding of HAdV vaccine immunogenicity and may provide pathways to extend the efficacy 2022-05-05T07:26:14Z 2022-05-05T07:26:14Z 2022 Bài trích https://journals.asm.org/doi/10.1128/jvi.01850-21 https://dlib.phenikaa-uni.edu.vn/handle/PNK/5735 https://doi.org/10.1128/jvi.01850-21 en American Society for Microbiology
institution	Digital Phenikaa
collection	Digital Phenikaa
language	English
topic	Adenovirus-α-Defensin NLRP3-Associated
spellingShingle	Adenovirus-α-Defensin NLRP3-Associated Karsten, Eichholz Tuan, Hiep Tran Coraline ,Chéneau Tran, Thi Thu Phuong Océane, Paris Martine, Pugniere Eric, J. Kremer Adenovirus-α-Defensin Complexes Induce NLRP3-Associated Maturation of Human Phagocytes via Toll-Like Receptor 4 Engagement
description	Intramuscular delivery of human adenovirus (HAdV)-based vaccines leads to rapid recruitment of neutrophils, which then release antimicrobial peptides/proteins (AMPs). How these AMPs influence vaccine efficacy over the subsequent 24 h is poorly understood. In this study, we asked if human neutrophil protein 1 (HNP-1), an α-defensin that influences direct and indirect innate immune responses to a range of pathogens, impacts the response of human phagocytes to three HAdV species/types (HAdV-C5, -D26, -B35). We show that HNP-1 binds to the capsids and redirects HAdV-C5, -D26, and -B35 to Toll-like receptor 4 (TLR4), which leads to internalization, an NLRP3-mediated inflammasome response, and interleukin 1 beta (IL-1β) release. Surprisingly, IL-1β release was not associated with notable disruption of plasma membrane integrity. These data further our understanding of HAdV vaccine immunogenicity and may provide pathways to extend the efficacy
format	Bài trích
author	Karsten, Eichholz Tuan, Hiep Tran Coraline ,Chéneau Tran, Thi Thu Phuong Océane, Paris Martine, Pugniere Eric, J. Kremer
author_facet	Karsten, Eichholz Tuan, Hiep Tran Coraline ,Chéneau Tran, Thi Thu Phuong Océane, Paris Martine, Pugniere Eric, J. Kremer
author_sort	Karsten, Eichholz
title	Adenovirus-α-Defensin Complexes Induce NLRP3-Associated Maturation of Human Phagocytes via Toll-Like Receptor 4 Engagement
title_short	Adenovirus-α-Defensin Complexes Induce NLRP3-Associated Maturation of Human Phagocytes via Toll-Like Receptor 4 Engagement
title_full	Adenovirus-α-Defensin Complexes Induce NLRP3-Associated Maturation of Human Phagocytes via Toll-Like Receptor 4 Engagement
title_fullStr	Adenovirus-α-Defensin Complexes Induce NLRP3-Associated Maturation of Human Phagocytes via Toll-Like Receptor 4 Engagement
title_full_unstemmed	Adenovirus-α-Defensin Complexes Induce NLRP3-Associated Maturation of Human Phagocytes via Toll-Like Receptor 4 Engagement
title_sort	adenovirus-α-defensin complexes induce nlrp3-associated maturation of human phagocytes via toll-like receptor 4 engagement
publisher	American Society for Microbiology
publishDate	2022
url	https://journals.asm.org/doi/10.1128/jvi.01850-21 https://dlib.phenikaa-uni.edu.vn/handle/PNK/5735 https://doi.org/10.1128/jvi.01850-21
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score	8.891145

Adenovirus-α-Defensin Complexes Induce NLRP3-Associated Maturation of Human Phagocytes via Toll-Like Receptor 4 Engagement

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