Novel 4-Oxoquinazoline-Based N-Hydroxypropenamides as Histone Deacetylase Inhibitors: Design, Synthesis, and Biological Evaluation
Two series of novel 4-oxoquinazoline-based N-hydroxypropenamides (9a–m and 10a–m) were designed, synthesized, and evaluated for their inhibitory and cytotoxicity activities against histone deacetylase (HDAC). The compounds showed good to potent HDAC inhib
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| Định dạng: | Bài trích |
| Ngôn ngữ: | eng |
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American Chemical Society
2021
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| Truy cập trực tuyến: | https://pubs.acs.org/doi/abs/10.1021/acsomega.0c05870 https://dlib.phenikaa-uni.edu.vn/handle/PNK/2748 https://doi.org/10.1021/acsomega.0c05870 |
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oai:localhost:PNK-27482022-08-17T05:54:47Z Novel 4-Oxoquinazoline-Based N-Hydroxypropenamides as Histone Deacetylase Inhibitors: Design, Synthesis, and Biological Evaluation Duong T. Anh Pham-The Hai Le D. Huy Hoang B. Ngoc Trinh T. M. Ngoc Do T. M. Dung Eun J. Park In K. Song Jong S. Kang Joo-Hee Kwon Truong T. Tung Sang-Bae Han Nguyen-Hai Nam Two series of novel 4-oxoquinazoline-based N-hydroxypropenamides (9a–m and 10a–m) were designed, synthesized, and evaluated for their inhibitory and cytotoxicity activities against histone deacetylase (HDAC). The compounds showed good to potent HDAC inhib 2021-09-10T04:46:53Z 2021-09-10T04:46:53Z 2021 Bài trích https://pubs.acs.org/doi/abs/10.1021/acsomega.0c05870 https://dlib.phenikaa-uni.edu.vn/handle/PNK/2748 https://doi.org/10.1021/acsomega.0c05870 eng application/pdf American Chemical Society |
| institution |
Digital Phenikaa |
| collection |
Digital Phenikaa |
| language |
eng |
| description |
Two series of novel 4-oxoquinazoline-based N-hydroxypropenamides (9a–m and 10a–m) were designed, synthesized, and evaluated for their inhibitory and cytotoxicity activities against histone deacetylase (HDAC). The compounds showed good to potent HDAC inhib |
| format |
Bài trích |
| author |
Duong T. Anh Pham-The Hai Le D. Huy Hoang B. Ngoc Trinh T. M. Ngoc Do T. M. Dung Eun J. Park In K. Song Jong S. Kang Joo-Hee Kwon Truong T. Tung Sang-Bae Han Nguyen-Hai Nam |
| spellingShingle |
Duong T. Anh Pham-The Hai Le D. Huy Hoang B. Ngoc Trinh T. M. Ngoc Do T. M. Dung Eun J. Park In K. Song Jong S. Kang Joo-Hee Kwon Truong T. Tung Sang-Bae Han Nguyen-Hai Nam Novel 4-Oxoquinazoline-Based N-Hydroxypropenamides as Histone Deacetylase Inhibitors: Design, Synthesis, and Biological Evaluation |
| author_facet |
Duong T. Anh Pham-The Hai Le D. Huy Hoang B. Ngoc Trinh T. M. Ngoc Do T. M. Dung Eun J. Park In K. Song Jong S. Kang Joo-Hee Kwon Truong T. Tung Sang-Bae Han Nguyen-Hai Nam |
| author_sort |
Duong T. Anh |
| title |
Novel 4-Oxoquinazoline-Based N-Hydroxypropenamides as Histone Deacetylase Inhibitors: Design, Synthesis, and Biological Evaluation |
| title_short |
Novel 4-Oxoquinazoline-Based N-Hydroxypropenamides as Histone Deacetylase Inhibitors: Design, Synthesis, and Biological Evaluation |
| title_full |
Novel 4-Oxoquinazoline-Based N-Hydroxypropenamides as Histone Deacetylase Inhibitors: Design, Synthesis, and Biological Evaluation |
| title_fullStr |
Novel 4-Oxoquinazoline-Based N-Hydroxypropenamides as Histone Deacetylase Inhibitors: Design, Synthesis, and Biological Evaluation |
| title_full_unstemmed |
Novel 4-Oxoquinazoline-Based N-Hydroxypropenamides as Histone Deacetylase Inhibitors: Design, Synthesis, and Biological Evaluation |
| title_sort |
novel 4-oxoquinazoline-based n-hydroxypropenamides as histone deacetylase inhibitors: design, synthesis, and biological evaluation |
| publisher |
American Chemical Society |
| publishDate |
2021 |
| url |
https://pubs.acs.org/doi/abs/10.1021/acsomega.0c05870 https://dlib.phenikaa-uni.edu.vn/handle/PNK/2748 https://doi.org/10.1021/acsomega.0c05870 |
| _version_ |
1751856263012024320 |
| score |
8.891787 |