Novel 4-Oxoquinazoline-Based N-Hydroxypropenamides as Histone Deacetylase Inhibitors: Design, Synthesis, and Biological Evaluation
Two series of novel 4-oxoquinazoline-based N-hydroxypropenamides (9a–m and 10a–m) were designed, synthesized, and evaluated for their inhibitory and cytotoxicity activities against histone deacetylase (HDAC). The compounds showed good to potent HDAC inhib
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Bài trích |
| Language: | eng |
| Published: |
American Chemical Society
2021
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| Online Access: | https://pubs.acs.org/doi/abs/10.1021/acsomega.0c05870 https://dlib.phenikaa-uni.edu.vn/handle/PNK/2748 https://doi.org/10.1021/acsomega.0c05870 |
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| Summary: | Two series of novel 4-oxoquinazoline-based N-hydroxypropenamides (9a–m and 10a–m) were designed, synthesized, and evaluated for their inhibitory and cytotoxicity activities against histone deacetylase (HDAC). The compounds showed good to potent HDAC inhib |
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