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“A new ursane-type triterpene from the danshen roots (Salvia miltiorrhiza Bunge)”. Records of Natural Products, 13 (2019) 429-433.

Danshen (Salvia miltiorrhiza) is a one of the most well-known medicinal herbs in the Oriental medicine for treatment of certain cardiovascular disoders. Our current research on triterpenoid component in danshen roots led to the isolation of a new highly hydroxylated ursane-type triterpene, urs-12,20...

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Main Author: Nguyen Huu Tung
Other Authors: Le Quoc Hung
Published: ACG Publications 2020
Online Access:https://dlib.phenikaa-uni.edu.vn/handle/PNK/243
https://doi.org/10.25135/rnp.97.18.07.330
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spelling oai:localhost:PNK-2432022-08-17T05:54:41Z “A new ursane-type triterpene from the danshen roots (Salvia miltiorrhiza Bunge)”. Records of Natural Products, 13 (2019) 429-433. Nguyen Huu Tung Le Quoc Hung Phuong Thien Thuong Danshen (Salvia miltiorrhiza) is a one of the most well-known medicinal herbs in the Oriental medicine for treatment of certain cardiovascular disoders. Our current research on triterpenoid component in danshen roots led to the isolation of a new highly hydroxylated ursane-type triterpene, urs-12,20(30)-dien-3β,7β,24-triol-28-oic acid (2) and one known triterpene, epiasiatic acid (1). Their structures were elucidated on the basis of extensive spectroscopic analyses including NMR and MS spectra and comparison with literature data. The new compound 2 showed medium activity against HL-60 cells with the IC50 value of 16.3 μM. The obtained results of unique bioactive triterpenes from danshen contributed not only to its phytochemical profile associated with chemotaxanomy but also to biological evidence of the title plant. 2020-04-29T07:52:23Z 2020-04-29T07:52:23Z 2018 bccb00177 https://dlib.phenikaa-uni.edu.vn/handle/PNK/243 https://doi.org/10.25135/rnp.97.18.07.330 application/pdf ACG Publications
institution Digital Phenikaa
collection Digital Phenikaa
description Danshen (Salvia miltiorrhiza) is a one of the most well-known medicinal herbs in the Oriental medicine for treatment of certain cardiovascular disoders. Our current research on triterpenoid component in danshen roots led to the isolation of a new highly hydroxylated ursane-type triterpene, urs-12,20(30)-dien-3β,7β,24-triol-28-oic acid (2) and one known triterpene, epiasiatic acid (1). Their structures were elucidated on the basis of extensive spectroscopic analyses including NMR and MS spectra and comparison with literature data. The new compound 2 showed medium activity against HL-60 cells with the IC50 value of 16.3 μM. The obtained results of unique bioactive triterpenes from danshen contributed not only to its phytochemical profile associated with chemotaxanomy but also to biological evidence of the title plant.
author2 Le Quoc Hung
author_facet Le Quoc Hung
Nguyen Huu Tung
author Nguyen Huu Tung
spellingShingle Nguyen Huu Tung
“A new ursane-type triterpene from the danshen roots (Salvia miltiorrhiza Bunge)”. Records of Natural Products, 13 (2019) 429-433.
author_sort Nguyen Huu Tung
title “A new ursane-type triterpene from the danshen roots (Salvia miltiorrhiza Bunge)”. Records of Natural Products, 13 (2019) 429-433.
title_short “A new ursane-type triterpene from the danshen roots (Salvia miltiorrhiza Bunge)”. Records of Natural Products, 13 (2019) 429-433.
title_full “A new ursane-type triterpene from the danshen roots (Salvia miltiorrhiza Bunge)”. Records of Natural Products, 13 (2019) 429-433.
title_fullStr “A new ursane-type triterpene from the danshen roots (Salvia miltiorrhiza Bunge)”. Records of Natural Products, 13 (2019) 429-433.
title_full_unstemmed “A new ursane-type triterpene from the danshen roots (Salvia miltiorrhiza Bunge)”. Records of Natural Products, 13 (2019) 429-433.
title_sort “a new ursane-type triterpene from the danshen roots (salvia miltiorrhiza bunge)”. records of natural products, 13 (2019) 429-433.
publisher ACG Publications
publishDate 2020
url https://dlib.phenikaa-uni.edu.vn/handle/PNK/243
https://doi.org/10.25135/rnp.97.18.07.330
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score 8.881002

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