pH-responsive nanocarriers for combined chemotherapies: a new approach with old materials
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| Đồng tác giả: | |
| Định dạng: | Bài Báo |
| Ngôn ngữ: | English |
| Nhà xuất bản: |
Cellulose
2021
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| Chủ đề: | |
| Truy cập trực tuyến: | https://link.springer.com/article/10.1007%2Fs10570-021-03769-y https://dlib.phenikaa-uni.edu.vn/handle/PNK/1960 https://doi.org/10.1007/s10570-021-03769-y |
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oai:localhost:PNK-19602022-08-17T05:54:44Z pH-responsive nanocarriers for combined chemotherapies: a new approach with old materials Trong Bien Tran Tuan Hiep Tran Yen Hai Vu Thien Giap Le Thao Thi Do Nga Thi Nguyen Thuan Thi Nguyen Tung Bao Pham Trung Quang Ngo Quang Anh Luong Chien Ngoc Nguyen Combination therapy Ethyl cellulose pH-responsive pH-responsive Q1 Ethyl cellulose (EC) is widely used in the pharmaceutical field as a polymeric excipient to fabricate sustained-release drug delivery systems. To develop a controlled release carrier exploiting the unique characteristic acidic environment of the target tumor site, this study examined the use of EC and lecithin (LC) as a nanoparticulated system. Paclitaxel and dihydroartemisinin were used as model drug combinations. The optimized formulated nanoparticles (NPs) of EC (EC NPs) and EC/LC (EC/LC NPs) were spherical and approximately 130 nm in diameter as determined by dynamic light scattering and electron microscopy analyses. The in vitro drug release from EC/LC NPs exhibited a pH-dependent pattern. In in vitro cell studies, the NPs were taken up by cells, and cell growth was inhibited by drugs released from the formulations. Most importantly, the in vivo anti-tumor study in mice showed a significant reduction in tumor volume after the intravenous administration of EC/LC NPs, suggesting the potential of using EC and LC as controlled and pH-sensitive drug delivery carriers. 2021-07-06T03:16:27Z 2021-07-06T03:16:27Z 2021 Article https://link.springer.com/article/10.1007%2Fs10570-021-03769-y https://dlib.phenikaa-uni.edu.vn/handle/PNK/1960 https://doi.org/10.1007/s10570-021-03769-y en application/pdf Cellulose |
| institution |
Digital Phenikaa |
| collection |
Digital Phenikaa |
| language |
English |
| topic |
Combination therapy Ethyl cellulose pH-responsive pH-responsive |
| spellingShingle |
Combination therapy Ethyl cellulose pH-responsive pH-responsive Trong Bien Tran pH-responsive nanocarriers for combined chemotherapies: a new approach with old materials |
| description |
Q1 |
| author2 |
Tuan Hiep Tran |
| author_facet |
Tuan Hiep Tran Trong Bien Tran |
| format |
Article |
| author |
Trong Bien Tran |
| author_sort |
Trong Bien Tran |
| title |
pH-responsive nanocarriers for combined chemotherapies: a new approach with old materials |
| title_short |
pH-responsive nanocarriers for combined chemotherapies: a new approach with old materials |
| title_full |
pH-responsive nanocarriers for combined chemotherapies: a new approach with old materials |
| title_fullStr |
pH-responsive nanocarriers for combined chemotherapies: a new approach with old materials |
| title_full_unstemmed |
pH-responsive nanocarriers for combined chemotherapies: a new approach with old materials |
| title_sort |
ph-responsive nanocarriers for combined chemotherapies: a new approach with old materials |
| publisher |
Cellulose |
| publishDate |
2021 |
| url |
https://link.springer.com/article/10.1007%2Fs10570-021-03769-y https://dlib.phenikaa-uni.edu.vn/handle/PNK/1960 https://doi.org/10.1007/s10570-021-03769-y |
| _version_ |
1751856298103668736 |
| score |
8.891787 |