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pH-responsive nanocarriers for combined chemotherapies: a new approach with old materials

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Bibliographic Details
Main Author: Trong Bien Tran
Other Authors: Tuan Hiep Tran
Format: Article
Language:English
Published: Cellulose 2021
Subjects:
Combination therapy
Ethyl cellulose
pH-responsive
Online Access:https://link.springer.com/article/10.1007%2Fs10570-021-03769-y
https://dlib.phenikaa-uni.edu.vn/handle/PNK/1960
https://doi.org/10.1007/s10570-021-03769-y
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spelling oai:localhost:PNK-19602022-08-17T05:54:44Z pH-responsive nanocarriers for combined chemotherapies: a new approach with old materials Trong Bien Tran Tuan Hiep Tran Yen Hai Vu Thien Giap Le Thao Thi Do Nga Thi Nguyen Thuan Thi Nguyen Tung Bao Pham Trung Quang Ngo Quang Anh Luong Chien Ngoc Nguyen Combination therapy Ethyl cellulose pH-responsive pH-responsive Q1 Ethyl cellulose (EC) is widely used in the pharmaceutical field as a polymeric excipient to fabricate sustained-release drug delivery systems. To develop a controlled release carrier exploiting the unique characteristic acidic environment of the target tumor site, this study examined the use of EC and lecithin (LC) as a nanoparticulated system. Paclitaxel and dihydroartemisinin were used as model drug combinations. The optimized formulated nanoparticles (NPs) of EC (EC NPs) and EC/LC (EC/LC NPs) were spherical and approximately 130 nm in diameter as determined by dynamic light scattering and electron microscopy analyses. The in vitro drug release from EC/LC NPs exhibited a pH-dependent pattern. In in vitro cell studies, the NPs were taken up by cells, and cell growth was inhibited by drugs released from the formulations. Most importantly, the in vivo anti-tumor study in mice showed a significant reduction in tumor volume after the intravenous administration of EC/LC NPs, suggesting the potential of using EC and LC as controlled and pH-sensitive drug delivery carriers. 2021-07-06T03:16:27Z 2021-07-06T03:16:27Z 2021 Article https://link.springer.com/article/10.1007%2Fs10570-021-03769-y https://dlib.phenikaa-uni.edu.vn/handle/PNK/1960 https://doi.org/10.1007/s10570-021-03769-y en application/pdf Cellulose
institution Digital Phenikaa
collection Digital Phenikaa
language English
topic Combination therapy
Ethyl cellulose
pH-responsive
pH-responsive
spellingShingle Combination therapy
Ethyl cellulose
pH-responsive
pH-responsive
Trong Bien Tran
pH-responsive nanocarriers for combined chemotherapies: a new approach with old materials
description Q1
author2 Tuan Hiep Tran
author_facet Tuan Hiep Tran
Trong Bien Tran
format Article
author Trong Bien Tran
author_sort Trong Bien Tran
title pH-responsive nanocarriers for combined chemotherapies: a new approach with old materials
title_short pH-responsive nanocarriers for combined chemotherapies: a new approach with old materials
title_full pH-responsive nanocarriers for combined chemotherapies: a new approach with old materials
title_fullStr pH-responsive nanocarriers for combined chemotherapies: a new approach with old materials
title_full_unstemmed pH-responsive nanocarriers for combined chemotherapies: a new approach with old materials
title_sort ph-responsive nanocarriers for combined chemotherapies: a new approach with old materials
publisher Cellulose
publishDate 2021
url https://link.springer.com/article/10.1007%2Fs10570-021-03769-y
https://dlib.phenikaa-uni.edu.vn/handle/PNK/1960
https://doi.org/10.1007/s10570-021-03769-y
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score 8.881002

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