Cover Image

Applied electric field analysis and numerical investigations of the continuous cell separation in a dielectrophoresis-based microfluidic channel

Q1

Saved in:
Bibliographic Details
Main Author: Ngoc-Viet Nguyen
Other Authors: Tu Le Manh
Format: Article
Language:English
Published: Journal of Science: Advanced Materials and Devices 2021
Subjects:
Continuous cell separation
Circulating tumor cells (CTCs)
Dielectrophoresis (DEP)
Numerical simulation
Online Access:https://www.sciencedirect.com/science/article/pii/S2468217920300940?via%3Dihub#!
https://dlib.phenikaa-uni.edu.vn/handle/PNK/1932
Tags: Add Tag
No Tags, Be the first to tag this record!
id oai:localhost:PNK-1932
record_format dspace
spelling oai:localhost:PNK-19322022-08-17T05:54:45Z Applied electric field analysis and numerical investigations of the continuous cell separation in a dielectrophoresis-based microfluidic channel Ngoc-Viet Nguyen Tu Le Manh Tang Son Nguyen Viet Thong Le Nguyen Van Hieu Continuous cell separation Circulating tumor cells (CTCs) Dielectrophoresis (DEP) Numerical simulation Q1 Dielectrophoresis (DEP) is known as an attractive and frugal technique to manipulate biological particles in microfluidics. This study presents the advanced solution strategy of a DEP-based microfluidic channel for focusing and separating cancerous cells in continuous flow. Theoretical calculations were carried out to define the favorable parameters in the electric field operation of the microchip. A simulation model was also used to explore the performance of the design in the isolation of circulating tumor cells (CTCs). It revealed that the optimal conditions of the device are suitable to effectively separate CTCs from red blood cells (RBCs) within the channel structure, with a high flow rate of 1.5 μL/min, and an electric amplitude as low as 10 Vpp, at the frequency of 1 kHz. The proposed method has shown potential as a simple, easy-to-operate, and low-cost approach enable to enhance the diagnosis systems for cancer detection at early stages. 2021-07-05T07:55:35Z 2021-07-05T07:55:35Z 2021 Article https://www.sciencedirect.com/science/article/pii/S2468217920300940?via%3Dihub#! https://dlib.phenikaa-uni.edu.vn/handle/PNK/1932 10.1016/j.jsamd.2020.11.002 en application/pdf application/pdf Journal of Science: Advanced Materials and Devices
institution Digital Phenikaa
collection Digital Phenikaa
language English
topic Continuous cell separation
Circulating tumor cells (CTCs)
Dielectrophoresis (DEP)
Numerical simulation
spellingShingle Continuous cell separation
Circulating tumor cells (CTCs)
Dielectrophoresis (DEP)
Numerical simulation
Ngoc-Viet Nguyen
Applied electric field analysis and numerical investigations of the continuous cell separation in a dielectrophoresis-based microfluidic channel
description Q1
author2 Tu Le Manh
author_facet Tu Le Manh
Ngoc-Viet Nguyen
format Article
author Ngoc-Viet Nguyen
author_sort Ngoc-Viet Nguyen
title Applied electric field analysis and numerical investigations of the continuous cell separation in a dielectrophoresis-based microfluidic channel
title_short Applied electric field analysis and numerical investigations of the continuous cell separation in a dielectrophoresis-based microfluidic channel
title_full Applied electric field analysis and numerical investigations of the continuous cell separation in a dielectrophoresis-based microfluidic channel
title_fullStr Applied electric field analysis and numerical investigations of the continuous cell separation in a dielectrophoresis-based microfluidic channel
title_full_unstemmed Applied electric field analysis and numerical investigations of the continuous cell separation in a dielectrophoresis-based microfluidic channel
title_sort applied electric field analysis and numerical investigations of the continuous cell separation in a dielectrophoresis-based microfluidic channel
publisher Journal of Science: Advanced Materials and Devices
publishDate 2021
url https://www.sciencedirect.com/science/article/pii/S2468217920300940?via%3Dihub#!
https://dlib.phenikaa-uni.edu.vn/handle/PNK/1932
_version_ 1751856255662555136
score 8.889492

Similar Items