Applied electric field analysis and numerical investigations of the continuous cell separation in a dielectrophoresis-based microfluidic channel
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Journal of Science: Advanced Materials and Devices
2021
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oai:localhost:PNK-19322022-08-17T05:54:45Z Applied electric field analysis and numerical investigations of the continuous cell separation in a dielectrophoresis-based microfluidic channel Ngoc-Viet Nguyen Tu Le Manh Tang Son Nguyen Viet Thong Le Nguyen Van Hieu Continuous cell separation Circulating tumor cells (CTCs) Dielectrophoresis (DEP) Numerical simulation Q1 Dielectrophoresis (DEP) is known as an attractive and frugal technique to manipulate biological particles in microfluidics. This study presents the advanced solution strategy of a DEP-based microfluidic channel for focusing and separating cancerous cells in continuous flow. Theoretical calculations were carried out to define the favorable parameters in the electric field operation of the microchip. A simulation model was also used to explore the performance of the design in the isolation of circulating tumor cells (CTCs). It revealed that the optimal conditions of the device are suitable to effectively separate CTCs from red blood cells (RBCs) within the channel structure, with a high flow rate of 1.5 μL/min, and an electric amplitude as low as 10 Vpp, at the frequency of 1 kHz. The proposed method has shown potential as a simple, easy-to-operate, and low-cost approach enable to enhance the diagnosis systems for cancer detection at early stages. 2021-07-05T07:55:35Z 2021-07-05T07:55:35Z 2021 Article https://www.sciencedirect.com/science/article/pii/S2468217920300940?via%3Dihub#! https://dlib.phenikaa-uni.edu.vn/handle/PNK/1932 10.1016/j.jsamd.2020.11.002 en application/pdf application/pdf Journal of Science: Advanced Materials and Devices |
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Continuous cell separation Circulating tumor cells (CTCs) Dielectrophoresis (DEP) Numerical simulation |
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Continuous cell separation Circulating tumor cells (CTCs) Dielectrophoresis (DEP) Numerical simulation Ngoc-Viet Nguyen Applied electric field analysis and numerical investigations of the continuous cell separation in a dielectrophoresis-based microfluidic channel |
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Q1 |
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Tu Le Manh |
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Tu Le Manh Ngoc-Viet Nguyen |
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Ngoc-Viet Nguyen |
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Ngoc-Viet Nguyen |
title |
Applied electric field analysis and numerical investigations of the continuous cell separation in a dielectrophoresis-based microfluidic channel |
title_short |
Applied electric field analysis and numerical investigations of the continuous cell separation in a dielectrophoresis-based microfluidic channel |
title_full |
Applied electric field analysis and numerical investigations of the continuous cell separation in a dielectrophoresis-based microfluidic channel |
title_fullStr |
Applied electric field analysis and numerical investigations of the continuous cell separation in a dielectrophoresis-based microfluidic channel |
title_full_unstemmed |
Applied electric field analysis and numerical investigations of the continuous cell separation in a dielectrophoresis-based microfluidic channel |
title_sort |
applied electric field analysis and numerical investigations of the continuous cell separation in a dielectrophoresis-based microfluidic channel |
publisher |
Journal of Science: Advanced Materials and Devices |
publishDate |
2021 |
url |
https://www.sciencedirect.com/science/article/pii/S2468217920300940?via%3Dihub#! https://dlib.phenikaa-uni.edu.vn/handle/PNK/1932 |
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1751856255662555136 |
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8.891145 |