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Targeting and internalizing PEGylated nanodrugs to enhance the therapeutic efficacy of hematologic malignancies by anti-PEG bispecific antibody (mPEG × CD20)

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Bibliographic Details
Main Authors: Chen, Huei-Jen, Cheng, Yi-An, Chen, Yu-Tung
Format: Book
Language:English
Published: Springer 2023
Subjects:
EPR effect
PEG-NPs
Online Access:https://link.springer.com/article/10.1186/s12645-023-00230-6
https://dlib.phenikaa-uni.edu.vn/handle/PNK/9506
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spelling oai:localhost:PNK-95062023-10-09T03:11:33Z Targeting and internalizing PEGylated nanodrugs to enhance the therapeutic efficacy of hematologic malignancies by anti-PEG bispecific antibody (mPEG × CD20) Chen, Huei-Jen Cheng, Yi-An Chen, Yu-Tung EPR effect PEG-NPs CC-BY PEGylated nanoparticles (PEG-NPs) are not effective for hematologic malignancies as they lack the enhanced permeability and retention effect (EPR effect). Tumor-targeted PEG-NPs can systemically track lymphoma and actively internalize into cancer cells to enhance therapeutic efficacy. We generated an anti-PEG bispecific antibody (BsAb; mPEG × CD20) which was able to simultaneously bind to methoxy PEG on liposomes and CD20 to form multivalent αCD20-armed liposomes. This αCD20-armed liposome was able to crosslink CD20 on lymphoma cells to enhance cellular internalization and the anti-cancer efficacy of the liposomes to lymphoma. We generated mPEG × CD20 and used this bispecific antibody to modify PEGylated liposomal doxorubicin (PLD) through a one-step formulation. 2023-10-09T03:11:33Z 2023-10-09T03:11:33Z 2023 Book https://link.springer.com/article/10.1186/s12645-023-00230-6 https://dlib.phenikaa-uni.edu.vn/handle/PNK/9506 en application/pdf Springer
institution Digital Phenikaa
collection Digital Phenikaa
language English
topic EPR effect
PEG-NPs
spellingShingle EPR effect
PEG-NPs
Chen, Huei-Jen
Cheng, Yi-An
Chen, Yu-Tung
Targeting and internalizing PEGylated nanodrugs to enhance the therapeutic efficacy of hematologic malignancies by anti-PEG bispecific antibody (mPEG × CD20)
description CC-BY
format Book
author Chen, Huei-Jen
Cheng, Yi-An
Chen, Yu-Tung
author_facet Chen, Huei-Jen
Cheng, Yi-An
Chen, Yu-Tung
author_sort Chen, Huei-Jen
title Targeting and internalizing PEGylated nanodrugs to enhance the therapeutic efficacy of hematologic malignancies by anti-PEG bispecific antibody (mPEG × CD20)
title_short Targeting and internalizing PEGylated nanodrugs to enhance the therapeutic efficacy of hematologic malignancies by anti-PEG bispecific antibody (mPEG × CD20)
title_full Targeting and internalizing PEGylated nanodrugs to enhance the therapeutic efficacy of hematologic malignancies by anti-PEG bispecific antibody (mPEG × CD20)
title_fullStr Targeting and internalizing PEGylated nanodrugs to enhance the therapeutic efficacy of hematologic malignancies by anti-PEG bispecific antibody (mPEG × CD20)
title_full_unstemmed Targeting and internalizing PEGylated nanodrugs to enhance the therapeutic efficacy of hematologic malignancies by anti-PEG bispecific antibody (mPEG × CD20)
title_sort targeting and internalizing pegylated nanodrugs to enhance the therapeutic efficacy of hematologic malignancies by anti-peg bispecific antibody (mpeg × cd20)
publisher Springer
publishDate 2023
url https://link.springer.com/article/10.1186/s12645-023-00230-6
https://dlib.phenikaa-uni.edu.vn/handle/PNK/9506
_version_ 1779397738911236096
score 8.893527

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