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Enhanced anti-glioma efficacy of biodegradable periodic mesoporous organosilica nanoparticles through target delivery of chemotherapeutics

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Main Authors: Dong, Min, Liu, Ying, Liu, Biao
Format: Book
Language:English
Published: Springer 2023
Subjects:
obtained PMO
PMO
Online Access:https://link.springer.com/article/10.1007/s10856-023-06747-x
https://dlib.phenikaa-uni.edu.vn/handle/PNK/9473
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spelling oai:localhost:PNK-94732023-10-05T06:59:36Z Enhanced anti-glioma efficacy of biodegradable periodic mesoporous organosilica nanoparticles through target delivery of chemotherapeutics Dong, Min Liu, Ying Liu, Biao obtained PMO PMO CC-BY Glioma is the most common malignant tumor of the brain and enhancing the efficacy of chemotherapy in glioma is critical for improving patients’ prognosis. In this study, a glioma-targeting drug delivery system is constructed using biodegradable periodic mesoporous organosilica nanoparticles (PMO) that are modified with lactoferrin (Lf) ligands. The obtained PMO is doped with thioether groups and can be degraded in the high concentration of glutathione in tumor cells. The surface area and pore volume of PMO are 772 cm2/g and 0.98 cm3/g, respectively and the loading capacity of doxorubicin (Dox) is as high as 20%. The results of the confocal laser scanning microscope show that the uptake of PMO-Lf@Dox by C6 cells is higher than PMO@Dox. 2023-10-05T06:59:35Z 2023-10-05T06:59:35Z 2023 Book https://link.springer.com/article/10.1007/s10856-023-06747-x https://dlib.phenikaa-uni.edu.vn/handle/PNK/9473 en application/pdf Springer
institution Digital Phenikaa
collection Digital Phenikaa
language English
topic obtained PMO
PMO
spellingShingle obtained PMO
PMO
Dong, Min
Liu, Ying
Liu, Biao
Enhanced anti-glioma efficacy of biodegradable periodic mesoporous organosilica nanoparticles through target delivery of chemotherapeutics
description CC-BY
format Book
author Dong, Min
Liu, Ying
Liu, Biao
author_facet Dong, Min
Liu, Ying
Liu, Biao
author_sort Dong, Min
title Enhanced anti-glioma efficacy of biodegradable periodic mesoporous organosilica nanoparticles through target delivery of chemotherapeutics
title_short Enhanced anti-glioma efficacy of biodegradable periodic mesoporous organosilica nanoparticles through target delivery of chemotherapeutics
title_full Enhanced anti-glioma efficacy of biodegradable periodic mesoporous organosilica nanoparticles through target delivery of chemotherapeutics
title_fullStr Enhanced anti-glioma efficacy of biodegradable periodic mesoporous organosilica nanoparticles through target delivery of chemotherapeutics
title_full_unstemmed Enhanced anti-glioma efficacy of biodegradable periodic mesoporous organosilica nanoparticles through target delivery of chemotherapeutics
title_sort enhanced anti-glioma efficacy of biodegradable periodic mesoporous organosilica nanoparticles through target delivery of chemotherapeutics
publisher Springer
publishDate 2023
url https://link.springer.com/article/10.1007/s10856-023-06747-x
https://dlib.phenikaa-uni.edu.vn/handle/PNK/9473
_version_ 1779307184758194176
score 8.891145

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