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Ascorbate oxidation driven by PM2.5-bound metal(loid)s extracted in an acidic simulated lung fluid in relation to their bioaccessibility

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Main Authors: Expósito, A., Markiv, B., Santibáñez, M.
Format: Book
Language:English
Published: Springer 2023
Subjects:
Ascorbate oxidation
their bioaccessibility
Online Access:https://link.springer.com/article/10.1007/s11869-023-01436-8
https://dlib.phenikaa-uni.edu.vn/handle/PNK/9398
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spelling oai:localhost:PNK-93982023-10-02T08:12:28Z Ascorbate oxidation driven by PM2.5-bound metal(loid)s extracted in an acidic simulated lung fluid in relation to their bioaccessibility Expósito, A. Markiv, B. Santibáñez, M. Ascorbate oxidation their bioaccessibility CC-BY The oxidative potential (OP) is defined as the ability of inhaled PM components to catalytically/non-catalytically generate reactive oxygen species (ROS) and deplete lung antioxidants. Although several studies have measured the OP of particulate matter (PM OP) soluble components using different antioxidants under neutral pH conditions, few studies have measured PM OP with acidic lung fluids. This study provides new insights into the use of acidic rather than neutral fluids in OP assays. Thus, the first aim of this study was to clarify the effect of using an acidic lung fluid on ascorbic acid (AA) depletion. This was achieved by measuring the oxidative potential (OP-AA) of individual compounds known to catalyze the AA oxidation (CuSO4, CuCl2, and 1,4-NQ) in artificial lysosomal fluid (ALF, pH 4.5), a commonly used acidic simulated lung fluid, and in a neutral fluid (phosphate-buffered saline (PBS1x), pH 7.4). 2023-10-02T08:12:28Z 2023-10-02T08:12:28Z 2023 Book https://link.springer.com/article/10.1007/s11869-023-01436-8 https://dlib.phenikaa-uni.edu.vn/handle/PNK/9398 en application/pdf Springer
institution Digital Phenikaa
collection Digital Phenikaa
language English
topic Ascorbate oxidation
their bioaccessibility
spellingShingle Ascorbate oxidation
their bioaccessibility
Expósito, A.
Markiv, B.
Santibáñez, M.
Ascorbate oxidation driven by PM2.5-bound metal(loid)s extracted in an acidic simulated lung fluid in relation to their bioaccessibility
description CC-BY
format Book
author Expósito, A.
Markiv, B.
Santibáñez, M.
author_facet Expósito, A.
Markiv, B.
Santibáñez, M.
author_sort Expósito, A.
title Ascorbate oxidation driven by PM2.5-bound metal(loid)s extracted in an acidic simulated lung fluid in relation to their bioaccessibility
title_short Ascorbate oxidation driven by PM2.5-bound metal(loid)s extracted in an acidic simulated lung fluid in relation to their bioaccessibility
title_full Ascorbate oxidation driven by PM2.5-bound metal(loid)s extracted in an acidic simulated lung fluid in relation to their bioaccessibility
title_fullStr Ascorbate oxidation driven by PM2.5-bound metal(loid)s extracted in an acidic simulated lung fluid in relation to their bioaccessibility
title_full_unstemmed Ascorbate oxidation driven by PM2.5-bound metal(loid)s extracted in an acidic simulated lung fluid in relation to their bioaccessibility
title_sort ascorbate oxidation driven by pm2.5-bound metal(loid)s extracted in an acidic simulated lung fluid in relation to their bioaccessibility
publisher Springer
publishDate 2023
url https://link.springer.com/article/10.1007/s11869-023-01436-8
https://dlib.phenikaa-uni.edu.vn/handle/PNK/9398
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score 8.887836

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