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Panax ginseng ameliorates hepatorenal oxidative alterations induced by commercially used cypermethrin in male rats: experimental and molecular docking approaches

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Main Authors: Elblehi, Samar S., Hafez, Mona H., El-Far, Ali H.
Format: Book
Language:English
Published: Springer 2023
Subjects:
CYP
Ginseng+CYP
Online Access:https://link.springer.com/article/10.1007/s11356-023-29935-2
https://dlib.phenikaa-uni.edu.vn/handle/PNK/9385
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spelling oai:localhost:PNK-93852023-10-02T02:24:59Z Panax ginseng ameliorates hepatorenal oxidative alterations induced by commercially used cypermethrin in male rats: experimental and molecular docking approaches Elblehi, Samar S. Hafez, Mona H. El-Far, Ali H. CYP Ginseng+CYP Cc-BY Cypermethrin (CYP) is a synthetic pyrethroid utilized as an insecticide in agriculture and various pest eradication programs. However, it induces numerous health hazards for animals and humans. Therefore, the current study used Panax ginseng root extract (ginseng) to reduce the hepatorenal damage caused by commercially used CYP. Thirty-two male Wistar albino rats were distributed into control, ginseng (300 mg/kg B.W/day), CYP (4.67 mg/kg B.W.), and Ginseng+CYP (rats received both CYP and ginseng). All treatments were administered orally for 30 consecutive days. Cypermethrin induced harmful effects on hepatic and renal tissues through a substantial decline in body weight in addition to a considerable increase in liver enzymes, functional renal markers, and cholesterol. Also, CYP significantly decreased acetylcholinesterase (AChE) activity and increased pro-inflammatory cytokines (interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α)). Moreover, a marked increase in malondialdehyde level with a significant drop in reduced glutathione level and total superoxide dismutase (T-SOD) and catalase (CAT) activities was reported in the CYP group in kidney and liver tissues. 2023-10-02T02:24:59Z 2023-10-02T02:24:59Z 2023 Book https://link.springer.com/article/10.1007/s11356-023-29935-2 https://dlib.phenikaa-uni.edu.vn/handle/PNK/9385 en application/pdf Springer
institution Digital Phenikaa
collection Digital Phenikaa
language English
topic CYP
Ginseng+CYP
spellingShingle CYP
Ginseng+CYP
Elblehi, Samar S.
Hafez, Mona H.
El-Far, Ali H.
Panax ginseng ameliorates hepatorenal oxidative alterations induced by commercially used cypermethrin in male rats: experimental and molecular docking approaches
description Cc-BY
format Book
author Elblehi, Samar S.
Hafez, Mona H.
El-Far, Ali H.
author_facet Elblehi, Samar S.
Hafez, Mona H.
El-Far, Ali H.
author_sort Elblehi, Samar S.
title Panax ginseng ameliorates hepatorenal oxidative alterations induced by commercially used cypermethrin in male rats: experimental and molecular docking approaches
title_short Panax ginseng ameliorates hepatorenal oxidative alterations induced by commercially used cypermethrin in male rats: experimental and molecular docking approaches
title_full Panax ginseng ameliorates hepatorenal oxidative alterations induced by commercially used cypermethrin in male rats: experimental and molecular docking approaches
title_fullStr Panax ginseng ameliorates hepatorenal oxidative alterations induced by commercially used cypermethrin in male rats: experimental and molecular docking approaches
title_full_unstemmed Panax ginseng ameliorates hepatorenal oxidative alterations induced by commercially used cypermethrin in male rats: experimental and molecular docking approaches
title_sort panax ginseng ameliorates hepatorenal oxidative alterations induced by commercially used cypermethrin in male rats: experimental and molecular docking approaches
publisher Springer
publishDate 2023
url https://link.springer.com/article/10.1007/s11356-023-29935-2
https://dlib.phenikaa-uni.edu.vn/handle/PNK/9385
_version_ 1779307176783773696
score 8.891053

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