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Enhanced supply of acetyl-CoA by exogenous pantothenate kinase promotes synthesis of poly(3-hydroxybutyrate)

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Bibliographic Details
Main Authors: Hirotaka, Kudo, Sho, Ono, Kenta, Abe
Format: Book
Language:English
Published: Springer 2023
Subjects:
CoA
CoaA
Online Access:https://link.springer.com/article/10.1186/s12934-023-02083-5
https://dlib.phenikaa-uni.edu.vn/handle/PNK/8177
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spelling oai:localhost:PNK-81772023-04-21T01:21:11Z Enhanced supply of acetyl-CoA by exogenous pantothenate kinase promotes synthesis of poly(3-hydroxybutyrate) Hirotaka, Kudo Sho, Ono Kenta, Abe CoA CoaA CC BY Coenzyme A (CoA) is a carrier of acyl groups. This cofactor is synthesized from pantothenic acid in five steps. The phosphorylation of pantothenate is catalyzed by pantothenate kinase (CoaA), which is a key step in the CoA biosynthetic pathway. To determine whether the enhancement of the CoA biosynthetic pathway is effective for producing useful substances, the effect of elevated acetyl-CoA levels resulting from the introduction of the exogenous coaA gene on poly(3-hydroxybutyrate) [P(3HB)] synthesis was determined in Escherichia coli, which express the genes necessary for cyanobacterial polyhydroxyalkanoate synthesis (phaABEC). 2023-04-21T01:21:11Z 2023-04-21T01:21:11Z 2023 Book https://link.springer.com/article/10.1186/s12934-023-02083-5 https://dlib.phenikaa-uni.edu.vn/handle/PNK/8177 en application/pdf Springer
institution Digital Phenikaa
collection Digital Phenikaa
language English
topic CoA
CoaA
spellingShingle CoA
CoaA
Hirotaka, Kudo
Sho, Ono
Kenta, Abe
Enhanced supply of acetyl-CoA by exogenous pantothenate kinase promotes synthesis of poly(3-hydroxybutyrate)
description CC BY
format Book
author Hirotaka, Kudo
Sho, Ono
Kenta, Abe
author_facet Hirotaka, Kudo
Sho, Ono
Kenta, Abe
author_sort Hirotaka, Kudo
title Enhanced supply of acetyl-CoA by exogenous pantothenate kinase promotes synthesis of poly(3-hydroxybutyrate)
title_short Enhanced supply of acetyl-CoA by exogenous pantothenate kinase promotes synthesis of poly(3-hydroxybutyrate)
title_full Enhanced supply of acetyl-CoA by exogenous pantothenate kinase promotes synthesis of poly(3-hydroxybutyrate)
title_fullStr Enhanced supply of acetyl-CoA by exogenous pantothenate kinase promotes synthesis of poly(3-hydroxybutyrate)
title_full_unstemmed Enhanced supply of acetyl-CoA by exogenous pantothenate kinase promotes synthesis of poly(3-hydroxybutyrate)
title_sort enhanced supply of acetyl-coa by exogenous pantothenate kinase promotes synthesis of poly(3-hydroxybutyrate)
publisher Springer
publishDate 2023
url https://link.springer.com/article/10.1186/s12934-023-02083-5
https://dlib.phenikaa-uni.edu.vn/handle/PNK/8177
_version_ 1763815057578262528
score 8.891787

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