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NIR-II-absorbing diimmonium polymer agent achieves excellent photothermal therapy with induction of tumor immunogenic cell death

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Bibliographic Details
Main Authors: Han, Xu, Huaping, Deng, Xiaoqian, Ma
Format: Book
Language:English
Published: Springer 2023
Subjects:
P-IDI
NIR-II
Online Access:https://link.springer.com/article/10.1186/s12951-023-01882-7
https://dlib.phenikaa-uni.edu.vn/handle/PNK/8176
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spelling oai:localhost:PNK-81762023-04-21T01:18:27Z NIR-II-absorbing diimmonium polymer agent achieves excellent photothermal therapy with induction of tumor immunogenic cell death Han, Xu Huaping, Deng Xiaoqian, Ma P-IDI NIR-II CC BY Photothermal therapy has shown great promise for cancer treatment and second near-infrared (NIR-II) -absorbing particles could further improve its precision and applicability due to its superior penetration depth and new imaging ability. Herein, high NIR-II-absorbing polymer particles were prepared by using soluble isobutyl-substituted diammonium borates (P-IDI). The P-IDI showed stronger absorption at 1000–1100 nm, which exhibited excellent photostability, strong photoacoustic imaging ability and high photothermal conversion efficiency (34.7%). The investigations in vitro and in vivo demonstrated that the excellent photothermal effect facilitated complete tumor ablation and also triggered immunogenic cell death in activation of the immune response. The high solubility and excellent photothermal conversion ability demonstrated that polymer IDI particles were promising theranostic agents for treatment of tumors with minor side effects. 2023-04-21T01:18:27Z 2023-04-21T01:18:27Z 2023 Book https://link.springer.com/article/10.1186/s12951-023-01882-7 https://dlib.phenikaa-uni.edu.vn/handle/PNK/8176 en application/pdf Springer
institution Digital Phenikaa
collection Digital Phenikaa
language English
topic P-IDI
NIR-II
spellingShingle P-IDI
NIR-II
Han, Xu
Huaping, Deng
Xiaoqian, Ma
NIR-II-absorbing diimmonium polymer agent achieves excellent photothermal therapy with induction of tumor immunogenic cell death
description CC BY
format Book
author Han, Xu
Huaping, Deng
Xiaoqian, Ma
author_facet Han, Xu
Huaping, Deng
Xiaoqian, Ma
author_sort Han, Xu
title NIR-II-absorbing diimmonium polymer agent achieves excellent photothermal therapy with induction of tumor immunogenic cell death
title_short NIR-II-absorbing diimmonium polymer agent achieves excellent photothermal therapy with induction of tumor immunogenic cell death
title_full NIR-II-absorbing diimmonium polymer agent achieves excellent photothermal therapy with induction of tumor immunogenic cell death
title_fullStr NIR-II-absorbing diimmonium polymer agent achieves excellent photothermal therapy with induction of tumor immunogenic cell death
title_full_unstemmed NIR-II-absorbing diimmonium polymer agent achieves excellent photothermal therapy with induction of tumor immunogenic cell death
title_sort nir-ii-absorbing diimmonium polymer agent achieves excellent photothermal therapy with induction of tumor immunogenic cell death
publisher Springer
publishDate 2023
url https://link.springer.com/article/10.1186/s12951-023-01882-7
https://dlib.phenikaa-uni.edu.vn/handle/PNK/8176
_version_ 1763815057485987840
score 8.881002

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