Point-of-care diagnosis and monitoring of fibrinolysis resistance in the critically ill: results from a feasibility study
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2023
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| Online Access: | https://link.springer.com/article/10.1186/s13054-023-04329-5 https://dlib.phenikaa-uni.edu.vn/handle/PNK/7078 |
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oai:localhost:PNK-70782023-03-23T02:03:07Z Point-of-care diagnosis and monitoring of fibrinolysis resistance in the critically ill: results from a feasibility study Lucy A., Coupland David J., Rabbolini Jonathan G., Schoenecker tissue plasminogen activator acute respiratory failure CC BY ibrinolysisis is essential for vascular blood flow maintenance and is triggered by endothelial and platelet release of tissue plasminogen activator (t-PA). In certain critical conditions, e.g. sepsis, acute respiratory failure (ARF) and trauma, the fibrinolytic response is reduced and may lead to widespread thrombosis and multi-organ failure. The mechanisms underpinning fibrinolysis resistance include reduced t-PA expression and/or release, reduced t-PA and/or plasmin effect due to elevated inhibitor levels, increased consumption and/or clearance. This study in critically ill patients with fibrinolysis resistance aimed to evaluate the ability of t-PA and plasminogen supplementation to restore fibrinolysis with assessment using point-of-care ClotPro viscoelastic testing (VET). 2023-03-23T02:03:07Z 2023-03-23T02:03:07Z 2023 Book https://link.springer.com/article/10.1186/s13054-023-04329-5 https://dlib.phenikaa-uni.edu.vn/handle/PNK/7078 en application/pdf Springer |
| institution |
Digital Phenikaa |
| collection |
Digital Phenikaa |
| language |
English |
| topic |
tissue plasminogen activator acute respiratory failure |
| spellingShingle |
tissue plasminogen activator acute respiratory failure Lucy A., Coupland David J., Rabbolini Jonathan G., Schoenecker Point-of-care diagnosis and monitoring of fibrinolysis resistance in the critically ill: results from a feasibility study |
| description |
CC BY |
| format |
Book |
| author |
Lucy A., Coupland David J., Rabbolini Jonathan G., Schoenecker |
| author_facet |
Lucy A., Coupland David J., Rabbolini Jonathan G., Schoenecker |
| author_sort |
Lucy A., Coupland |
| title |
Point-of-care diagnosis and monitoring of fibrinolysis resistance in the critically ill: results from a feasibility study |
| title_short |
Point-of-care diagnosis and monitoring of fibrinolysis resistance in the critically ill: results from a feasibility study |
| title_full |
Point-of-care diagnosis and monitoring of fibrinolysis resistance in the critically ill: results from a feasibility study |
| title_fullStr |
Point-of-care diagnosis and monitoring of fibrinolysis resistance in the critically ill: results from a feasibility study |
| title_full_unstemmed |
Point-of-care diagnosis and monitoring of fibrinolysis resistance in the critically ill: results from a feasibility study |
| title_sort |
point-of-care diagnosis and monitoring of fibrinolysis resistance in the critically ill: results from a feasibility study |
| publisher |
Springer |
| publishDate |
2023 |
| url |
https://link.springer.com/article/10.1186/s13054-023-04329-5 https://dlib.phenikaa-uni.edu.vn/handle/PNK/7078 |
| _version_ |
1761187735546101760 |
| score |
8.891145 |