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P-15 promotes chondrocyte proliferation in osteoarthritis by regulating SFPQ to target the Akt-RUNX2 axis

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Main Authors: Junlan, Nie, Changgong, Deng, Hong, Li
Format: Book
Language:English
Published: Springer 2023
Subjects:
P-15 promotes
regulating SFPQ
Online Access:https://link.springer.com/article/10.1186/s13018-023-03658-z
https://dlib.phenikaa-uni.edu.vn/handle/PNK/6904
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spelling oai:localhost:PNK-69042023-03-16T06:39:47Z P-15 promotes chondrocyte proliferation in osteoarthritis by regulating SFPQ to target the Akt-RUNX2 axis Junlan, Nie Changgong, Deng Hong, Li P-15 promotes regulating SFPQ CC BY Osteoarthritis (OA) is a chronic joint disease characterized by degenerative articular cartilage changes and secondary hyperosteogeny [1], affecting 10–15% of adults over the age of 60 worldwide [2]. OA is a major cause of disability, and its incidence, which is related to sex, age, obesity, joint trauma, and other factors, is on the rise, bringing a huge economic burden to patients and society [3, 4]. The pathogenesis of OA involves a redox state imbalance leading to oxidative stress, aging, and apoptosis in chondrocytes, as well as decreased anabolism and increased catabolism of the extracellular matrix [5, 6]. After articular cartilage injury, it is mainly repaired by the proliferation and differentiation of chondrocytes. However, the proliferative capacity of chondrocytes is limited, and the quality and quantity of chondrocytes directly affect the repair [7]. Therefore, regulating chondrocyte proliferation and elucidating its molecular mechanism are of great significance for developing effective therapeutic strategies. 2023-03-16T04:17:33Z 2023-03-16T04:17:33Z 2023 Book https://link.springer.com/article/10.1186/s13018-023-03658-z https://dlib.phenikaa-uni.edu.vn/handle/PNK/6904 en application/pdf Springer
institution Digital Phenikaa
collection Digital Phenikaa
language English
topic P-15 promotes
regulating SFPQ
spellingShingle P-15 promotes
regulating SFPQ
Junlan, Nie
Changgong, Deng
Hong, Li
P-15 promotes chondrocyte proliferation in osteoarthritis by regulating SFPQ to target the Akt-RUNX2 axis
description CC BY
format Book
author Junlan, Nie
Changgong, Deng
Hong, Li
author_facet Junlan, Nie
Changgong, Deng
Hong, Li
author_sort Junlan, Nie
title P-15 promotes chondrocyte proliferation in osteoarthritis by regulating SFPQ to target the Akt-RUNX2 axis
title_short P-15 promotes chondrocyte proliferation in osteoarthritis by regulating SFPQ to target the Akt-RUNX2 axis
title_full P-15 promotes chondrocyte proliferation in osteoarthritis by regulating SFPQ to target the Akt-RUNX2 axis
title_fullStr P-15 promotes chondrocyte proliferation in osteoarthritis by regulating SFPQ to target the Akt-RUNX2 axis
title_full_unstemmed P-15 promotes chondrocyte proliferation in osteoarthritis by regulating SFPQ to target the Akt-RUNX2 axis
title_sort p-15 promotes chondrocyte proliferation in osteoarthritis by regulating sfpq to target the akt-runx2 axis
publisher Springer
publishDate 2023
url https://link.springer.com/article/10.1186/s13018-023-03658-z
https://dlib.phenikaa-uni.edu.vn/handle/PNK/6904
_version_ 1760553557745991680
score 8.881002

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