Intranasal delivery of pro-resolving lipid mediators rescues memory and gamma oscillation impairment in AppNL-G-F/NL-G-F mice
Sustained microglial activation and increased pro-inflammatory signalling cause chronic inflammation and neuronal damage in Alzheimer’s disease (AD). Resolution of inflammation follows neutralization of pathogens and is a response to limit damage and promote healing, mediated by pro-resolving lipid...
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Springer
2022
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| Truy cập trực tuyến: | https://www.nature.com/articles/s42003-022-03169-3 https://dlib.phenikaa-uni.edu.vn/handle/PNK/5974 https://doi.org/10.1038/s42003-022-03169-3 |
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oai:localhost:PNK-59742022-08-17T05:54:51Z Intranasal delivery of pro-resolving lipid mediators rescues memory and gamma oscillation impairment in AppNL-G-F/NL-G-F mice Ceren, Emre Luis E. Arroyo-García Khanh V. Do Molecular neuroscience Neuroimmunology Sustained microglial activation and increased pro-inflammatory signalling cause chronic inflammation and neuronal damage in Alzheimer’s disease (AD). Resolution of inflammation follows neutralization of pathogens and is a response to limit damage and promote healing, mediated by pro-resolving lipid mediators (LMs). Since resolution is impaired in AD brains, we decided to test if intranasal administration of pro-resolving LMs in the AppNL-G-F/NL-G-F mouse model for AD could resolve inflammation and ameliorate pathology in the brain. A mixture of the pro-resolving LMs resolvin (Rv) E1, RvD1, RvD2, maresin 1 (MaR1) and neuroprotectin D1 (NPD1) was administered to stimulate their respective receptors. We examined amyloid load, cognition, neuronal network oscillations, glial activation and inflammatory factors 2022-07-13T02:00:11Z 2022-07-13T02:00:11Z 2022 Bài trích https://www.nature.com/articles/s42003-022-03169-3 https://dlib.phenikaa-uni.edu.vn/handle/PNK/5974 https://doi.org/10.1038/s42003-022-03169-3 en Springer |
| institution |
Digital Phenikaa |
| collection |
Digital Phenikaa |
| language |
English |
| topic |
Molecular neuroscience Neuroimmunology |
| spellingShingle |
Molecular neuroscience Neuroimmunology Ceren, Emre Luis E. Arroyo-García Khanh V. Do Intranasal delivery of pro-resolving lipid mediators rescues memory and gamma oscillation impairment in AppNL-G-F/NL-G-F mice |
| description |
Sustained microglial activation and increased pro-inflammatory signalling cause chronic inflammation and neuronal damage in Alzheimer’s disease (AD). Resolution of inflammation follows neutralization of pathogens and is a response to limit damage and promote healing, mediated by pro-resolving lipid mediators (LMs). Since resolution is impaired in AD brains, we decided to test if intranasal administration of pro-resolving LMs in the AppNL-G-F/NL-G-F mouse model for AD could resolve inflammation and ameliorate pathology in the brain. A mixture of the pro-resolving LMs resolvin (Rv) E1, RvD1, RvD2, maresin 1 (MaR1) and neuroprotectin D1 (NPD1) was administered to stimulate their respective receptors. We examined amyloid load, cognition, neuronal network oscillations, glial activation and inflammatory factors |
| format |
Bài trích |
| author |
Ceren, Emre Luis E. Arroyo-García Khanh V. Do |
| author_facet |
Ceren, Emre Luis E. Arroyo-García Khanh V. Do |
| author_sort |
Ceren, Emre |
| title |
Intranasal delivery of pro-resolving lipid mediators rescues memory and gamma oscillation impairment in AppNL-G-F/NL-G-F mice |
| title_short |
Intranasal delivery of pro-resolving lipid mediators rescues memory and gamma oscillation impairment in AppNL-G-F/NL-G-F mice |
| title_full |
Intranasal delivery of pro-resolving lipid mediators rescues memory and gamma oscillation impairment in AppNL-G-F/NL-G-F mice |
| title_fullStr |
Intranasal delivery of pro-resolving lipid mediators rescues memory and gamma oscillation impairment in AppNL-G-F/NL-G-F mice |
| title_full_unstemmed |
Intranasal delivery of pro-resolving lipid mediators rescues memory and gamma oscillation impairment in AppNL-G-F/NL-G-F mice |
| title_sort |
intranasal delivery of pro-resolving lipid mediators rescues memory and gamma oscillation impairment in appnl-g-f/nl-g-f mice |
| publisher |
Springer |
| publishDate |
2022 |
| url |
https://www.nature.com/articles/s42003-022-03169-3 https://dlib.phenikaa-uni.edu.vn/handle/PNK/5974 https://doi.org/10.1038/s42003-022-03169-3 |
| _version_ |
1751856320177242112 |
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8.893527 |