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Intranasal delivery of pro-resolving lipid mediators rescues memory and gamma oscillation impairment in AppNL-G-F/NL-G-F mice

Sustained microglial activation and increased pro-inflammatory signalling cause chronic inflammation and neuronal damage in Alzheimer’s disease (AD). Resolution of inflammation follows neutralization of pathogens and is a response to limit damage and promote healing, mediated by pro-resolving lipid...

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Main Authors: Ceren, Emre, Luis E. Arroyo-García, Khanh V. Do
Format: Bài trích
Language:English
Published: Springer 2022
Subjects:
Molecular neuroscience
Neuroimmunology
Online Access:https://www.nature.com/articles/s42003-022-03169-3
https://dlib.phenikaa-uni.edu.vn/handle/PNK/5974
https://doi.org/10.1038/s42003-022-03169-3
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spelling oai:localhost:PNK-59742022-08-17T05:54:51Z Intranasal delivery of pro-resolving lipid mediators rescues memory and gamma oscillation impairment in AppNL-G-F/NL-G-F mice Ceren, Emre Luis E. Arroyo-García Khanh V. Do Molecular neuroscience Neuroimmunology Sustained microglial activation and increased pro-inflammatory signalling cause chronic inflammation and neuronal damage in Alzheimer’s disease (AD). Resolution of inflammation follows neutralization of pathogens and is a response to limit damage and promote healing, mediated by pro-resolving lipid mediators (LMs). Since resolution is impaired in AD brains, we decided to test if intranasal administration of pro-resolving LMs in the AppNL-G-F/NL-G-F mouse model for AD could resolve inflammation and ameliorate pathology in the brain. A mixture of the pro-resolving LMs resolvin (Rv) E1, RvD1, RvD2, maresin 1 (MaR1) and neuroprotectin D1 (NPD1) was administered to stimulate their respective receptors. We examined amyloid load, cognition, neuronal network oscillations, glial activation and inflammatory factors 2022-07-13T02:00:11Z 2022-07-13T02:00:11Z 2022 Bài trích https://www.nature.com/articles/s42003-022-03169-3 https://dlib.phenikaa-uni.edu.vn/handle/PNK/5974 https://doi.org/10.1038/s42003-022-03169-3 en Springer
institution Digital Phenikaa
collection Digital Phenikaa
language English
topic Molecular neuroscience
Neuroimmunology
spellingShingle Molecular neuroscience
Neuroimmunology
Ceren, Emre
Luis E. Arroyo-García
Khanh V. Do
Intranasal delivery of pro-resolving lipid mediators rescues memory and gamma oscillation impairment in AppNL-G-F/NL-G-F mice
description Sustained microglial activation and increased pro-inflammatory signalling cause chronic inflammation and neuronal damage in Alzheimer’s disease (AD). Resolution of inflammation follows neutralization of pathogens and is a response to limit damage and promote healing, mediated by pro-resolving lipid mediators (LMs). Since resolution is impaired in AD brains, we decided to test if intranasal administration of pro-resolving LMs in the AppNL-G-F/NL-G-F mouse model for AD could resolve inflammation and ameliorate pathology in the brain. A mixture of the pro-resolving LMs resolvin (Rv) E1, RvD1, RvD2, maresin 1 (MaR1) and neuroprotectin D1 (NPD1) was administered to stimulate their respective receptors. We examined amyloid load, cognition, neuronal network oscillations, glial activation and inflammatory factors
format Bài trích
author Ceren, Emre
Luis E. Arroyo-García
Khanh V. Do
author_facet Ceren, Emre
Luis E. Arroyo-García
Khanh V. Do
author_sort Ceren, Emre
title Intranasal delivery of pro-resolving lipid mediators rescues memory and gamma oscillation impairment in AppNL-G-F/NL-G-F mice
title_short Intranasal delivery of pro-resolving lipid mediators rescues memory and gamma oscillation impairment in AppNL-G-F/NL-G-F mice
title_full Intranasal delivery of pro-resolving lipid mediators rescues memory and gamma oscillation impairment in AppNL-G-F/NL-G-F mice
title_fullStr Intranasal delivery of pro-resolving lipid mediators rescues memory and gamma oscillation impairment in AppNL-G-F/NL-G-F mice
title_full_unstemmed Intranasal delivery of pro-resolving lipid mediators rescues memory and gamma oscillation impairment in AppNL-G-F/NL-G-F mice
title_sort intranasal delivery of pro-resolving lipid mediators rescues memory and gamma oscillation impairment in appnl-g-f/nl-g-f mice
publisher Springer
publishDate 2022
url https://www.nature.com/articles/s42003-022-03169-3
https://dlib.phenikaa-uni.edu.vn/handle/PNK/5974
https://doi.org/10.1038/s42003-022-03169-3
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score 8.891053

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