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Preventing Dementia Using Saffron, The Kampo Medicine, Kamiuntanto, and Their Combination, Kamiuntantokabankoka

The objective of this review is to evaluate the anti-dementia activities of saffron and its combination with Kampo medicine. The Kampo formula Kamiuntanto composed of 13 crude drugs is well known for its anti-dementia activity. A significant increase in choline acetyltransferase activity and mRNA le...

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Main Authors:	Kenny, Kuchta, Kosuke, Aritake, Yoshihiro, Urade
Format:	Bài trích
Language:	English
Published:	Frontiers Media S.A 2022
Subjects:	Kamiuntanto Kamiuntantokabankoka
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2021.779821/full https://dlib.phenikaa-uni.edu.vn/handle/PNK/5906 https://doi.org/10.3389/fphar.2021.779821
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spelling	oai:localhost:PNK-59062022-08-17T05:54:55Z Preventing Dementia Using Saffron, The Kampo Medicine, Kamiuntanto, and Their Combination, Kamiuntantokabankoka Kenny, Kuchta Kosuke, Aritake Yoshihiro, Urade Kamiuntanto Kamiuntantokabankoka The objective of this review is to evaluate the anti-dementia activities of saffron and its combination with Kampo medicine. The Kampo formula Kamiuntanto composed of 13 crude drugs is well known for its anti-dementia activity. A significant increase in choline acetyltransferase activity and mRNA levels were observed. Polygala radix was identified as the most essential component drug in Kamiuntanto, probably due to the saponins, tenuifolin, and sinapinic acid. Ginseng was also identified as an essential Kamiuntanto component in terms of its synergistic functions with Polygala radix. Saffron, which was recommended in the Bencao Gangmu for memory and dementia, and is used as an anti-spasmodic, anti-catarrhal, and sedative herbal drug. Saffron and its major constituent, crocin were shown to enhance learning-memory, non-rapid eye movement (rem) sleep, and inhibit depression and neuronal cell death due to strong anti-oxidant and anti-inflammation activities. In addition based on the epidemiological studies such as the treatment of sleeping disorders and the clinical trials of saffron for Alzheimer patients, we demonstrated the indirect and direct anti-dementia activities of crocin and saffron 2022-07-13T01:59:52Z 2022-07-13T01:59:52Z 2022 Bài trích https://www.frontiersin.org/articles/10.3389/fphar.2021.779821/full https://dlib.phenikaa-uni.edu.vn/handle/PNK/5906 https://doi.org/10.3389/fphar.2021.779821 en Frontiers Media S.A
institution	Digital Phenikaa
collection	Digital Phenikaa
language	English
topic	Kamiuntanto Kamiuntantokabankoka
spellingShingle	Kamiuntanto Kamiuntantokabankoka Kenny, Kuchta Kosuke, Aritake Yoshihiro, Urade Preventing Dementia Using Saffron, The Kampo Medicine, Kamiuntanto, and Their Combination, Kamiuntantokabankoka
description	The objective of this review is to evaluate the anti-dementia activities of saffron and its combination with Kampo medicine. The Kampo formula Kamiuntanto composed of 13 crude drugs is well known for its anti-dementia activity. A significant increase in choline acetyltransferase activity and mRNA levels were observed. Polygala radix was identified as the most essential component drug in Kamiuntanto, probably due to the saponins, tenuifolin, and sinapinic acid. Ginseng was also identified as an essential Kamiuntanto component in terms of its synergistic functions with Polygala radix. Saffron, which was recommended in the Bencao Gangmu for memory and dementia, and is used as an anti-spasmodic, anti-catarrhal, and sedative herbal drug. Saffron and its major constituent, crocin were shown to enhance learning-memory, non-rapid eye movement (rem) sleep, and inhibit depression and neuronal cell death due to strong anti-oxidant and anti-inflammation activities. In addition based on the epidemiological studies such as the treatment of sleeping disorders and the clinical trials of saffron for Alzheimer patients, we demonstrated the indirect and direct anti-dementia activities of crocin and saffron
format	Bài trích
author	Kenny, Kuchta Kosuke, Aritake Yoshihiro, Urade
author_facet	Kenny, Kuchta Kosuke, Aritake Yoshihiro, Urade
author_sort	Kenny, Kuchta
title	Preventing Dementia Using Saffron, The Kampo Medicine, Kamiuntanto, and Their Combination, Kamiuntantokabankoka
title_short	Preventing Dementia Using Saffron, The Kampo Medicine, Kamiuntanto, and Their Combination, Kamiuntantokabankoka
title_full	Preventing Dementia Using Saffron, The Kampo Medicine, Kamiuntanto, and Their Combination, Kamiuntantokabankoka
title_fullStr	Preventing Dementia Using Saffron, The Kampo Medicine, Kamiuntanto, and Their Combination, Kamiuntantokabankoka
title_full_unstemmed	Preventing Dementia Using Saffron, The Kampo Medicine, Kamiuntanto, and Their Combination, Kamiuntantokabankoka
title_sort	preventing dementia using saffron, the kampo medicine, kamiuntanto, and their combination, kamiuntantokabankoka
publisher	Frontiers Media S.A
publishDate	2022
url	https://www.frontiersin.org/articles/10.3389/fphar.2021.779821/full https://dlib.phenikaa-uni.edu.vn/handle/PNK/5906 https://doi.org/10.3389/fphar.2021.779821
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score	8.887836

Preventing Dementia Using Saffron, The Kampo Medicine, Kamiuntanto, and Their Combination, Kamiuntantokabankoka

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