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Formulation and characterization of hydroxyethyl cellulose-based gel containing metronidazole-loaded solid lipid nanoparticles for buccal mucosal drug delivery

Local delivery of drug is a promising strategy to manage periodontitis characterized by chronic inflammation of the soft tissue surrounding the teeth. An optimized system should prolong the drug retention time and exhibit controlled drug permeation through the buccal mucosal layer. This study was ai...

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Main Authors: Hoang, Nhan Hoa, Hoang Hao, Le, Thien Giap, Le
Format: Bài trích
Language:English
Published: Elsevier 2022
Subjects:
Hydroxyethyl cellulose
Solid lipid nanoparticle
Online Access:https://www.sciencedirect.com/science/article/abs/pii/S0141813021025678?via%3Dihub
https://dlib.phenikaa-uni.edu.vn/handle/PNK/5876
https://doi.org/10.1016/j.ijbiomac.2021.11.161
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spelling oai:localhost:PNK-58762022-08-17T05:54:54Z Formulation and characterization of hydroxyethyl cellulose-based gel containing metronidazole-loaded solid lipid nanoparticles for buccal mucosal drug delivery Hoang, Nhan Hoa Hoang Hao, Le Thien Giap, Le Hydroxyethyl cellulose Solid lipid nanoparticle Local delivery of drug is a promising strategy to manage periodontitis characterized by chronic inflammation of the soft tissue surrounding the teeth. An optimized system should prolong the drug retention time and exhibit controlled drug permeation through the buccal mucosal layer. This study was aimed to develop hydroxyethyl cellulose (HEC)-based gel containing metronidazole (MTZ) loaded in solid lipid nanoparticles (SLNs), and to enhance the antimicrobial activity of MTZ. SLNs were prepared using a combination method of solvent evaporation and hot homogenization. The results showed that the fabricated SLNs, comprising of Precirol (2.93%, w/v), Tween 80 (1.8%, w/v), and the drug:lipid ratio of 19.3% (w/w), were approximately 200 nm in size, with a narrow distribution. The HEC (3%, w/w)-based gel formed a smooth, homogeneous structure and had preferable mechanical and rheological properties. Moreover, the MTZ-loaded SLNs-based HEC gel (equivalent to 1% of MTZ, w/w) exhibited a sustained in vitro drug release pattern, optimal ex vivo permeability, and enhanced in vitro antimicrobial activity after 24 h of treatment. These findings indicate the potential of the MTZ-loaded SLNs-based HEC formulation for local drug delivery at the buccal mucosa in managing periodontal disease. 2022-07-13T01:59:47Z 2022-07-13T01:59:47Z 2022 Bài trích https://www.sciencedirect.com/science/article/abs/pii/S0141813021025678?via%3Dihub https://dlib.phenikaa-uni.edu.vn/handle/PNK/5876 https://doi.org/10.1016/j.ijbiomac.2021.11.161 en Elsevier
institution Digital Phenikaa
collection Digital Phenikaa
language English
topic Hydroxyethyl cellulose
Solid lipid nanoparticle
spellingShingle Hydroxyethyl cellulose
Solid lipid nanoparticle
Hoang, Nhan Hoa
Hoang Hao, Le
Thien Giap, Le
Formulation and characterization of hydroxyethyl cellulose-based gel containing metronidazole-loaded solid lipid nanoparticles for buccal mucosal drug delivery
description Local delivery of drug is a promising strategy to manage periodontitis characterized by chronic inflammation of the soft tissue surrounding the teeth. An optimized system should prolong the drug retention time and exhibit controlled drug permeation through the buccal mucosal layer. This study was aimed to develop hydroxyethyl cellulose (HEC)-based gel containing metronidazole (MTZ) loaded in solid lipid nanoparticles (SLNs), and to enhance the antimicrobial activity of MTZ. SLNs were prepared using a combination method of solvent evaporation and hot homogenization. The results showed that the fabricated SLNs, comprising of Precirol (2.93%, w/v), Tween 80 (1.8%, w/v), and the drug:lipid ratio of 19.3% (w/w), were approximately 200 nm in size, with a narrow distribution. The HEC (3%, w/w)-based gel formed a smooth, homogeneous structure and had preferable mechanical and rheological properties. Moreover, the MTZ-loaded SLNs-based HEC gel (equivalent to 1% of MTZ, w/w) exhibited a sustained in vitro drug release pattern, optimal ex vivo permeability, and enhanced in vitro antimicrobial activity after 24 h of treatment. These findings indicate the potential of the MTZ-loaded SLNs-based HEC formulation for local drug delivery at the buccal mucosa in managing periodontal disease.
format Bài trích
author Hoang, Nhan Hoa
Hoang Hao, Le
Thien Giap, Le
author_facet Hoang, Nhan Hoa
Hoang Hao, Le
Thien Giap, Le
author_sort Hoang, Nhan Hoa
title Formulation and characterization of hydroxyethyl cellulose-based gel containing metronidazole-loaded solid lipid nanoparticles for buccal mucosal drug delivery
title_short Formulation and characterization of hydroxyethyl cellulose-based gel containing metronidazole-loaded solid lipid nanoparticles for buccal mucosal drug delivery
title_full Formulation and characterization of hydroxyethyl cellulose-based gel containing metronidazole-loaded solid lipid nanoparticles for buccal mucosal drug delivery
title_fullStr Formulation and characterization of hydroxyethyl cellulose-based gel containing metronidazole-loaded solid lipid nanoparticles for buccal mucosal drug delivery
title_full_unstemmed Formulation and characterization of hydroxyethyl cellulose-based gel containing metronidazole-loaded solid lipid nanoparticles for buccal mucosal drug delivery
title_sort formulation and characterization of hydroxyethyl cellulose-based gel containing metronidazole-loaded solid lipid nanoparticles for buccal mucosal drug delivery
publisher Elsevier
publishDate 2022
url https://www.sciencedirect.com/science/article/abs/pii/S0141813021025678?via%3Dihub
https://dlib.phenikaa-uni.edu.vn/handle/PNK/5876
https://doi.org/10.1016/j.ijbiomac.2021.11.161
_version_ 1751856285581574144
score 8.881002

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