Preventing Dementia Using Saffron, The Kampo Medicine, Kamiuntanto, and Their Combination, Kamiuntantokabankoka
The objective of this review is to evaluate the anti-dementia activities of saffron and its combination with Kampo medicine. The Kampo formula Kamiuntanto composed of 13 crude drugs is well known for its anti-dementia activity. A significant increase in choline acetyltransferase activity and mRNA le...
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Frontiers Media
2022
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| Truy cập trực tuyến: | https://www.frontiersin.org/articles/10.3389/fphar.2021.779821/full#h1 https://dlib.phenikaa-uni.edu.vn/handle/PNK/5762 https://doi.org/10.3389/fphar.2021.779821 |
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oai:localhost:PNK-57622022-08-17T05:54:53Z Preventing Dementia Using Saffron, The Kampo Medicine, Kamiuntanto, and Their Combination, Kamiuntantokabankoka Kenny, Kuchta Kosuke, Aritake Yoshihiro, Urade Nguyen, Huu Tung Chun, Su Yuan Yui, Sasaki Koichi, Shimizu Yukihiro, Shoyama Dementia Using The Kampo Medicine The objective of this review is to evaluate the anti-dementia activities of saffron and its combination with Kampo medicine. The Kampo formula Kamiuntanto composed of 13 crude drugs is well known for its anti-dementia activity. A significant increase in choline acetyltransferase activity and mRNA levels were observed. Polygala radix was identified as the most essential component drug in Kamiuntanto, probably due to the saponins, tenuifolin, and sinapinic acid. Ginseng was also identified as an essential Kamiuntanto component in terms of its synergistic functions with Polygala radix. Saffron, which was recommended in the Bencao Gangmu for memory and dementia, and is used as an anti-spasmodic, anti-catarrhal, and sedative herbal drug. Saffron and its major constituent, crocin were shown to enhance learning-memory, non-rapid eye movement (rem) sleep, and inhibit depression and neuronal cell death due to strong anti-oxidant and anti-inflammation activities. In addition based on the epidemiological studies such as the treatment of sleeping disorders and the clinical trials of saffron for Alzheimer patients, we demonstrated the indirect and direct anti-dementia activities of crocin and saffron. 2022-05-05T07:26:20Z 2022-05-05T07:26:20Z 2022 Bài trích https://www.frontiersin.org/articles/10.3389/fphar.2021.779821/full#h1 https://dlib.phenikaa-uni.edu.vn/handle/PNK/5762 https://doi.org/10.3389/fphar.2021.779821 en Frontiers Media |
| institution |
Digital Phenikaa |
| collection |
Digital Phenikaa |
| language |
English |
| topic |
Dementia Using The Kampo Medicine |
| spellingShingle |
Dementia Using The Kampo Medicine Kenny, Kuchta Kosuke, Aritake Yoshihiro, Urade Nguyen, Huu Tung Chun, Su Yuan Yui, Sasaki Koichi, Shimizu Yukihiro, Shoyama Preventing Dementia Using Saffron, The Kampo Medicine, Kamiuntanto, and Their Combination, Kamiuntantokabankoka |
| description |
The objective of this review is to evaluate the anti-dementia activities of saffron and its combination with Kampo medicine. The Kampo formula Kamiuntanto composed of 13 crude drugs is well known for its anti-dementia activity. A significant increase in choline acetyltransferase activity and mRNA levels were observed. Polygala radix was identified as the most essential component drug in Kamiuntanto, probably due to the saponins, tenuifolin, and sinapinic acid. Ginseng was also identified as an essential Kamiuntanto component in terms of its synergistic functions with Polygala radix. Saffron, which was recommended in the Bencao Gangmu for memory and dementia, and is used as an anti-spasmodic, anti-catarrhal, and sedative herbal drug. Saffron and its major constituent, crocin were shown to enhance learning-memory, non-rapid eye movement (rem) sleep, and inhibit depression and neuronal cell death due to strong anti-oxidant and anti-inflammation activities. In addition based on the epidemiological studies such as the treatment of sleeping disorders and the clinical trials of saffron for Alzheimer patients, we demonstrated the indirect and direct anti-dementia activities of crocin and saffron. |
| format |
Bài trích |
| author |
Kenny, Kuchta Kosuke, Aritake Yoshihiro, Urade Nguyen, Huu Tung Chun, Su Yuan Yui, Sasaki Koichi, Shimizu Yukihiro, Shoyama |
| author_facet |
Kenny, Kuchta Kosuke, Aritake Yoshihiro, Urade Nguyen, Huu Tung Chun, Su Yuan Yui, Sasaki Koichi, Shimizu Yukihiro, Shoyama |
| author_sort |
Kenny, Kuchta |
| title |
Preventing Dementia Using Saffron, The Kampo Medicine, Kamiuntanto, and Their Combination, Kamiuntantokabankoka |
| title_short |
Preventing Dementia Using Saffron, The Kampo Medicine, Kamiuntanto, and Their Combination, Kamiuntantokabankoka |
| title_full |
Preventing Dementia Using Saffron, The Kampo Medicine, Kamiuntanto, and Their Combination, Kamiuntantokabankoka |
| title_fullStr |
Preventing Dementia Using Saffron, The Kampo Medicine, Kamiuntanto, and Their Combination, Kamiuntantokabankoka |
| title_full_unstemmed |
Preventing Dementia Using Saffron, The Kampo Medicine, Kamiuntanto, and Their Combination, Kamiuntantokabankoka |
| title_sort |
preventing dementia using saffron, the kampo medicine, kamiuntanto, and their combination, kamiuntantokabankoka |
| publisher |
Frontiers Media |
| publishDate |
2022 |
| url |
https://www.frontiersin.org/articles/10.3389/fphar.2021.779821/full#h1 https://dlib.phenikaa-uni.edu.vn/handle/PNK/5762 https://doi.org/10.3389/fphar.2021.779821 |
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1751856281897926656 |
| score |
8.891145 |