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Design, Synthesis and Evaluation of Novel (E)-N'-((1-(4-chlorobenzyl)-1H-indol-3- yl)methylene)-2-(4-oxoquinazolin-3(4H)-yl)acetohydrazides as Antitumor Agents

Herein, we have designed and synthesized a series of the novel (E)-N'-((1-(4-chlorobenzyl)- 1H-indol-3-yl)methylene)-2-(4-oxoquinazolin-3(4H)-yl)acetohydrazides (5) as potent small molecules activating procaspase- 3. The compounds were designed by the amalgamation of structural features of PAC-...

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Main Authors: Do, Thi Mai Dung, Eun, Jae Park, Duong, Tien Anh, Pham, The Hai, Le, Quang Bao
Format: Bài trích
Language:English
Published: Bentham Science Publishers 2022
Subjects:
Acetohydrazides
Quinazolin-4(3H)-one
Online Access:https://www.eurekaselect.com/article/120263
https://dlib.phenikaa-uni.edu.vn/handle/PNK/5726
http://dx.doi.org/10.2174/1871520622666220118154914
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spelling oai:localhost:PNK-57262022-08-17T05:54:50Z Design, Synthesis and Evaluation of Novel (E)-N'-((1-(4-chlorobenzyl)-1H-indol-3- yl)methylene)-2-(4-oxoquinazolin-3(4H)-yl)acetohydrazides as Antitumor Agents Do, Thi Mai Dung Eun, Jae Park Duong, Tien Anh Pham, The Hai Le, Quang Bao Acetohydrazides Quinazolin-4(3H)-one Herein, we have designed and synthesized a series of the novel (E)-N'-((1-(4-chlorobenzyl)- 1H-indol-3-yl)methylene)-2-(4-oxoquinazolin-3(4H)-yl)acetohydrazides (5) as potent small molecules activating procaspase- 3. The compounds were designed by the amalgamation of structural features of PAC-1 (the first procaspase-3 activator) and oncrasin-1, one potential anticancer agent 2022-05-05T07:26:13Z 2022-05-05T07:26:13Z 2022 Bài trích https://www.eurekaselect.com/article/120263 https://dlib.phenikaa-uni.edu.vn/handle/PNK/5726 http://dx.doi.org/10.2174/1871520622666220118154914 en Bentham Science Publishers
institution Digital Phenikaa
collection Digital Phenikaa
language English
topic Acetohydrazides
Quinazolin-4(3H)-one
spellingShingle Acetohydrazides
Quinazolin-4(3H)-one
Do, Thi Mai Dung
Eun, Jae Park
Duong, Tien Anh
Pham, The Hai
Le, Quang Bao
Design, Synthesis and Evaluation of Novel (E)-N'-((1-(4-chlorobenzyl)-1H-indol-3- yl)methylene)-2-(4-oxoquinazolin-3(4H)-yl)acetohydrazides as Antitumor Agents
description Herein, we have designed and synthesized a series of the novel (E)-N'-((1-(4-chlorobenzyl)- 1H-indol-3-yl)methylene)-2-(4-oxoquinazolin-3(4H)-yl)acetohydrazides (5) as potent small molecules activating procaspase- 3. The compounds were designed by the amalgamation of structural features of PAC-1 (the first procaspase-3 activator) and oncrasin-1, one potential anticancer agent
format Bài trích
author Do, Thi Mai Dung
Eun, Jae Park
Duong, Tien Anh
Pham, The Hai
Le, Quang Bao
author_facet Do, Thi Mai Dung
Eun, Jae Park
Duong, Tien Anh
Pham, The Hai
Le, Quang Bao
author_sort Do, Thi Mai Dung
title Design, Synthesis and Evaluation of Novel (E)-N'-((1-(4-chlorobenzyl)-1H-indol-3- yl)methylene)-2-(4-oxoquinazolin-3(4H)-yl)acetohydrazides as Antitumor Agents
title_short Design, Synthesis and Evaluation of Novel (E)-N'-((1-(4-chlorobenzyl)-1H-indol-3- yl)methylene)-2-(4-oxoquinazolin-3(4H)-yl)acetohydrazides as Antitumor Agents
title_full Design, Synthesis and Evaluation of Novel (E)-N'-((1-(4-chlorobenzyl)-1H-indol-3- yl)methylene)-2-(4-oxoquinazolin-3(4H)-yl)acetohydrazides as Antitumor Agents
title_fullStr Design, Synthesis and Evaluation of Novel (E)-N'-((1-(4-chlorobenzyl)-1H-indol-3- yl)methylene)-2-(4-oxoquinazolin-3(4H)-yl)acetohydrazides as Antitumor Agents
title_full_unstemmed Design, Synthesis and Evaluation of Novel (E)-N'-((1-(4-chlorobenzyl)-1H-indol-3- yl)methylene)-2-(4-oxoquinazolin-3(4H)-yl)acetohydrazides as Antitumor Agents
title_sort design, synthesis and evaluation of novel (e)-n'-((1-(4-chlorobenzyl)-1h-indol-3- yl)methylene)-2-(4-oxoquinazolin-3(4h)-yl)acetohydrazides as antitumor agents
publisher Bentham Science Publishers
publishDate 2022
url https://www.eurekaselect.com/article/120263
https://dlib.phenikaa-uni.edu.vn/handle/PNK/5726
http://dx.doi.org/10.2174/1871520622666220118154914
_version_ 1751856313314312192
score 8.893527

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