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Amide bond formation in aqueous solution: direct coupling of metal carboxylate salts with ammonium salts at room temperature

19, 10073-10080

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Bibliographic Details
Main Authors: Truong Thanh. Tung, John Nielsen
Format: Bài báo khoa học
Language:English
Published: Royal Society of Chemistry 2022
Subjects:
Carboxylate
Ammonium salts
Online Access:https://dlib.phenikaa-uni.edu.vn/handle/PNK/4010
https://doi.org/10.1039/D1OB02064A
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spelling oai:localhost:PNK-40102022-08-17T05:54:48Z Amide bond formation in aqueous solution: direct coupling of metal carboxylate salts with ammonium salts at room temperature Truong Thanh. Tung John Nielsen Carboxylate Ammonium salts 19, 10073-10080 Herein, we report a green, expeditious, and practically simple protocol for direct coupling of carboxylate salts and ammonium salts under ACN/H2O conditions at room temperature without the addition of tertiary amine bases. The water-soluble coupling reagent EDC·HCl is a key component in the reaction. The reaction runs smoothly with unsubstituted/substituted ammonium salts and provides a clean product without column chromatography. Our reaction tolerates both carboxylate (which are unstable in other forms) and amine salts (which are unstable/volatile when present in free form). We believe that the reported method could be used as an alternative and suitable method at the laboratory and industrial scales 2022-01-17T02:27:18Z 2022-01-17T02:27:18Z 2021 Bài báo khoa học https://dlib.phenikaa-uni.edu.vn/handle/PNK/4010 https://doi.org/10.1039/D1OB02064A en Royal Society of Chemistry
institution Digital Phenikaa
collection Digital Phenikaa
language English
topic Carboxylate
Ammonium salts
spellingShingle Carboxylate
Ammonium salts
Truong Thanh. Tung
John Nielsen
Amide bond formation in aqueous solution: direct coupling of metal carboxylate salts with ammonium salts at room temperature
description 19, 10073-10080
format Bài báo khoa học
author Truong Thanh. Tung
John Nielsen
author_facet Truong Thanh. Tung
John Nielsen
author_sort Truong Thanh. Tung
title Amide bond formation in aqueous solution: direct coupling of metal carboxylate salts with ammonium salts at room temperature
title_short Amide bond formation in aqueous solution: direct coupling of metal carboxylate salts with ammonium salts at room temperature
title_full Amide bond formation in aqueous solution: direct coupling of metal carboxylate salts with ammonium salts at room temperature
title_fullStr Amide bond formation in aqueous solution: direct coupling of metal carboxylate salts with ammonium salts at room temperature
title_full_unstemmed Amide bond formation in aqueous solution: direct coupling of metal carboxylate salts with ammonium salts at room temperature
title_sort amide bond formation in aqueous solution: direct coupling of metal carboxylate salts with ammonium salts at room temperature
publisher Royal Society of Chemistry
publishDate 2022
url https://dlib.phenikaa-uni.edu.vn/handle/PNK/4010
https://doi.org/10.1039/D1OB02064A
_version_ 1751856271682699264
score 8.891145

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