Staff View: The “Left-hand strategy” for design, synthesis and discovery of novel triazole-mercaptobenzothiazole hybrid compounds as potent quorum sensing inhibitors and anti-biofilm formation of Pseudomonas aeruginosa

The “Left-hand strategy” for design, synthesis and discovery of novel triazole-mercaptobenzothiazole hybrid compounds as potent quorum sensing inhibitors and anti-biofilm formation of Pseudomonas aeruginosa

45, 21631-21637

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Bibliographic Details
Main Authors:	Truong, Thanh Tung, Huy, Luong Xuan
Format:	Bài báo khoa học
Language:	English
Published:	New Journal of Chemistry 2022
Subjects:	Biological Triazole-mercaptobenzothiazole
Online Access:	https://dlib.phenikaa-uni.edu.vn/handle/PNK/4006 https://doi.org/10.1039/D1NJ04436B
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spelling	oai:localhost:PNK-40062022-08-17T05:54:47Z The “Left-hand strategy” for design, synthesis and discovery of novel triazole-mercaptobenzothiazole hybrid compounds as potent quorum sensing inhibitors and anti-biofilm formation of Pseudomonas aeruginosa Truong, Thanh Tung Huy, Luong Xuan Biological Triazole-mercaptobenzothiazole 45, 21631-21637 Herein, a library of novel hybrid 6-(4-substituted-1H-1,2,3-triazol-1-yl)-2-mercaptobenzothiazoles was designed using a “left-hand strategy” and synthesized using microwave-assisted synthesis. The synthesized compounds were screened against quorum sensing activities and biofilm formation of Gram-negative bacteria. Biological results reveal that eleven compounds strongly inhibited the quorum sensing activities of the Pseudomonas aeruginosa lasB-gfp reporter strain.Compounds 4g (IC50 of 9.84 ± 1.10 μM), 4h (IC50 of 6.09 ± 0.98 μM), and 4m (IC50 of 12.20 ± 0.25 μM) are 2–5 times stronger than the reference compound 4NPO (IC50 of 32 ± 0.88 μM) in QSI screening. Compounds 4g and 4h inhibited up to 90% of the biofilm formation of Pseudomonas aeruginosa. In terms of anti-virulence effects, compounds 4g and 4h strongly inhibited the production of violacein by Chromobacterium violaceum and protease by Pseudomonas aeruginosa.. 2022-01-17T02:27:18Z 2022-01-17T02:27:18Z 2021 Bài báo khoa học https://dlib.phenikaa-uni.edu.vn/handle/PNK/4006 https://doi.org/10.1039/D1NJ04436B en New Journal of Chemistry
institution	Digital Phenikaa
collection	Digital Phenikaa
language	English
topic	Biological Triazole-mercaptobenzothiazole
spellingShingle	Biological Triazole-mercaptobenzothiazole Truong, Thanh Tung Huy, Luong Xuan The “Left-hand strategy” for design, synthesis and discovery of novel triazole-mercaptobenzothiazole hybrid compounds as potent quorum sensing inhibitors and anti-biofilm formation of Pseudomonas aeruginosa
description	45, 21631-21637
format	Bài báo khoa học
author	Truong, Thanh Tung Huy, Luong Xuan
author_facet	Truong, Thanh Tung Huy, Luong Xuan
author_sort	Truong, Thanh Tung
title	The “Left-hand strategy” for design, synthesis and discovery of novel triazole-mercaptobenzothiazole hybrid compounds as potent quorum sensing inhibitors and anti-biofilm formation of Pseudomonas aeruginosa
title_short	The “Left-hand strategy” for design, synthesis and discovery of novel triazole-mercaptobenzothiazole hybrid compounds as potent quorum sensing inhibitors and anti-biofilm formation of Pseudomonas aeruginosa
title_full	The “Left-hand strategy” for design, synthesis and discovery of novel triazole-mercaptobenzothiazole hybrid compounds as potent quorum sensing inhibitors and anti-biofilm formation of Pseudomonas aeruginosa
title_fullStr	The “Left-hand strategy” for design, synthesis and discovery of novel triazole-mercaptobenzothiazole hybrid compounds as potent quorum sensing inhibitors and anti-biofilm formation of Pseudomonas aeruginosa
title_full_unstemmed	The “Left-hand strategy” for design, synthesis and discovery of novel triazole-mercaptobenzothiazole hybrid compounds as potent quorum sensing inhibitors and anti-biofilm formation of Pseudomonas aeruginosa
title_sort	“left-hand strategy” for design, synthesis and discovery of novel triazole-mercaptobenzothiazole hybrid compounds as potent quorum sensing inhibitors and anti-biofilm formation of pseudomonas aeruginosa
publisher	New Journal of Chemistry
publishDate	2022
url	https://dlib.phenikaa-uni.edu.vn/handle/PNK/4006 https://doi.org/10.1039/D1NJ04436B
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score	8.891787

The “Left-hand strategy” for design, synthesis and discovery of novel triazole-mercaptobenzothiazole hybrid compounds as potent quorum sensing inhibitors and anti-biofilm formation of Pseudomonas aeruginosa

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