2-Difluoromethylpyridine as a bioisosteric replacement of pyridine-N-oxide: the case of quorum sensing inhibitors
Herein, we demonstrate that 2-difluoromethylpyridine is a bioisosteric replacement of pyridine-N-oxide. Using the quorum sensing inhibitor 4NPO as a model compound, a library of 2-difluoromethylpyridine derivatives was designed, synthesized, and evaluated toward quorum sensing activity, biofilm form...
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| Main Authors: | , |
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| Format: | Bài trích |
| Language: | English |
| Published: |
RSC Medicinal Chemistry
2021
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| Online Access: | https://pubs.rsc.org/en/content/articlelanding/2021/MD/D1MD00245G https://dlib.phenikaa-uni.edu.vn/handle/PNK/3295 https://doi.org/10.1039/D1MD00245G |
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