2-Difluoromethylpyridine as a bioisosteric replacement of pyridine-N-oxide: the case of quorum sensing inhibitors

Herein, we demonstrate that 2-difluoromethylpyridine is a bioisosteric replacement of pyridine-N-oxide. Using the quorum sensing inhibitor 4NPO as a model compound, a library of 2-difluoromethylpyridine derivatives was designed, synthesized, and evaluated toward quorum sensing activity, biofilm form...

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Bibliographic Details
Main Authors: Truong Thanh Tung, Thang Nguyen Quoc
Format: Bài trích
Language:English
Published: RSC Medicinal Chemistry 2021
Online Access:https://pubs.rsc.org/en/content/articlelanding/2021/MD/D1MD00245G
https://dlib.phenikaa-uni.edu.vn/handle/PNK/3295
https://doi.org/10.1039/D1MD00245G
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