Staff View: Molecular networking-based chemical profiling and anti-influenza viral and neuroprotective effects of Elaeocarpus hygrophilus Kurz.

Molecular networking-based chemical profiling and anti-influenza viral and neuroprotective effects of Elaeocarpus hygrophilus Kurz.

Elaeocarpus hygrophilus Kurz. is a tropical tree that has recently been used for food and medicinal purposes. This study aimed to reveal the phytochemicals and evaluate the anti-influenza viral and neuroprotective effects of different parts of this plant including leaves, stems, fruit peels, and see...

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Main Authors:	Thi Kim Quy Ha, Thi Phuong Doan, Ha Thanh Tung Pham, Ngoc Hieu Nguyen, Trong Tuan Nguyen, Thi Buu Hue Bui
Format:	Bài trích
Language:	eng
Published:	Chemical Papers 2021
Subjects:	Neuraminidase inhibitors Neuroprotective effects molecular networking
Online Access:	https://link.springer.com/article/10.1007%2Fs11696-021-01723-7 https://dlib.phenikaa-uni.edu.vn/handle/PNK/2818 https://doi.org/10.1007/s11696-021-01723-7
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spelling	oai:localhost:PNK-28182022-08-17T05:54:48Z Molecular networking-based chemical profiling and anti-influenza viral and neuroprotective effects of Elaeocarpus hygrophilus Kurz. Thi Kim Quy Ha Thi Phuong Doan Ha Thanh Tung Pham Ngoc Hieu Nguyen Trong Tuan Nguyen Thi Buu Hue Bui Neuraminidase inhibitors Neuroprotective effects molecular networking Elaeocarpus hygrophilus Kurz. is a tropical tree that has recently been used for food and medicinal purposes. This study aimed to reveal the phytochemicals and evaluate the anti-influenza viral and neuroprotective effects of different parts of this plant including leaves, stems, fruit peels, and seeds. The study results indicated that the leaf extract was a potential candidate in the inhibition of the influenza viral replication through anti-neuraminidase receptors and attenuation of the glutamate-induced neuronal cell death and cellular oxidative stress. Using molecular networking as well as fragmentation, twenty-six known compounds were dereplicated from the leaves of E. hygrophilus. Molecular docking simulations of target proteins (PDB: 3CL0 and 4CXT) with these predicted compounds indicated that phenolic compounds from the EtOH leaf extract may be considered as active components for treating not only neuraminidase inhibitor-resistant strains but also activating Keap1/Nrf2 pathway. The anti-influenza viral and neuroprotective effects of the leaf extract and the link between the two activities could significantly contribute to the development of natural product drugs for influenza treatment and prevention of neuropsychiatric adverse events. These results suggested further research about the phytochemicals and the bio-guided isolation of the most active fractions from the leaf extract and their respective herbal drug formulations, with effective and secure aspects, to low-income populations of the tropics. 2021-09-13T04:24:47Z 2021-09-13T04:24:47Z 2021 Bài trích https://link.springer.com/article/10.1007%2Fs11696-021-01723-7 https://dlib.phenikaa-uni.edu.vn/handle/PNK/2818 https://doi.org/10.1007/s11696-021-01723-7 eng Chemical Papers
institution	Digital Phenikaa
collection	Digital Phenikaa
language	eng
topic	Neuraminidase inhibitors Neuroprotective effects molecular networking
spellingShingle	Neuraminidase inhibitors Neuroprotective effects molecular networking Thi Kim Quy Ha Thi Phuong Doan Ha Thanh Tung Pham Ngoc Hieu Nguyen Trong Tuan Nguyen Thi Buu Hue Bui Molecular networking-based chemical profiling and anti-influenza viral and neuroprotective effects of Elaeocarpus hygrophilus Kurz.
description	Elaeocarpus hygrophilus Kurz. is a tropical tree that has recently been used for food and medicinal purposes. This study aimed to reveal the phytochemicals and evaluate the anti-influenza viral and neuroprotective effects of different parts of this plant including leaves, stems, fruit peels, and seeds. The study results indicated that the leaf extract was a potential candidate in the inhibition of the influenza viral replication through anti-neuraminidase receptors and attenuation of the glutamate-induced neuronal cell death and cellular oxidative stress. Using molecular networking as well as fragmentation, twenty-six known compounds were dereplicated from the leaves of E. hygrophilus. Molecular docking simulations of target proteins (PDB: 3CL0 and 4CXT) with these predicted compounds indicated that phenolic compounds from the EtOH leaf extract may be considered as active components for treating not only neuraminidase inhibitor-resistant strains but also activating Keap1/Nrf2 pathway. The anti-influenza viral and neuroprotective effects of the leaf extract and the link between the two activities could significantly contribute to the development of natural product drugs for influenza treatment and prevention of neuropsychiatric adverse events. These results suggested further research about the phytochemicals and the bio-guided isolation of the most active fractions from the leaf extract and their respective herbal drug formulations, with effective and secure aspects, to low-income populations of the tropics.
format	Bài trích
author	Thi Kim Quy Ha Thi Phuong Doan Ha Thanh Tung Pham Ngoc Hieu Nguyen Trong Tuan Nguyen Thi Buu Hue Bui
author_facet	Thi Kim Quy Ha Thi Phuong Doan Ha Thanh Tung Pham Ngoc Hieu Nguyen Trong Tuan Nguyen Thi Buu Hue Bui
author_sort	Thi Kim Quy Ha
title	Molecular networking-based chemical profiling and anti-influenza viral and neuroprotective effects of Elaeocarpus hygrophilus Kurz.
title_short	Molecular networking-based chemical profiling and anti-influenza viral and neuroprotective effects of Elaeocarpus hygrophilus Kurz.
title_full	Molecular networking-based chemical profiling and anti-influenza viral and neuroprotective effects of Elaeocarpus hygrophilus Kurz.
title_fullStr	Molecular networking-based chemical profiling and anti-influenza viral and neuroprotective effects of Elaeocarpus hygrophilus Kurz.
title_full_unstemmed	Molecular networking-based chemical profiling and anti-influenza viral and neuroprotective effects of Elaeocarpus hygrophilus Kurz.
title_sort	molecular networking-based chemical profiling and anti-influenza viral and neuroprotective effects of elaeocarpus hygrophilus kurz.
publisher	Chemical Papers
publishDate	2021
url	https://link.springer.com/article/10.1007%2Fs11696-021-01723-7 https://dlib.phenikaa-uni.edu.vn/handle/PNK/2818 https://doi.org/10.1007/s11696-021-01723-7
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score	8.891053

Molecular networking-based chemical profiling and anti-influenza viral and neuroprotective effects of Elaeocarpus hygrophilus Kurz.

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