Staff View: Discovery of novel β-turn mimetic-based peptides as novel quorum sensing inhibitors of gram-negative bacteria

Discovery of novel β-turn mimetic-based peptides as novel quorum sensing inhibitors of gram-negative bacteria

To date, a very limited number of peptides reported as quorum sensing inhibitors. Herein, we report the synthesis and evaluation of a series of β-turn mimetic-based peptides as potent quorum sensing inhibitors and antibiofilm formation. In this series, peptides P1, P4, and P5 showed very promising a...

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Bibliographic Details
Main Authors:	Truong Thanh Tung, Thang Nguyen Quoc
Format:	Bài trích
Language:	eng
Published:	Bioorganic & Medicinal Chemistry Letters 2021
Subjects:	Synthesis Anti-biofilm Β-turn
Online Access:	https://www.sciencedirect.com/science/article/abs/pii/S0960894X21003978?via%3Dihub https://dlib.phenikaa-uni.edu.vn/handle/PNK/2814 https://doi.org/10.1016/j.bmcl.2021.128170
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spelling	oai:localhost:PNK-28142022-08-17T05:54:48Z Discovery of novel β-turn mimetic-based peptides as novel quorum sensing inhibitors of gram-negative bacteria Truong Thanh Tung Thang Nguyen Quoc Synthesis Anti-biofilm Β-turn To date, a very limited number of peptides reported as quorum sensing inhibitors. Herein, we report the synthesis and evaluation of a series of β-turn mimetic-based peptides as potent quorum sensing inhibitors and antibiofilm formation. In this series, peptides P1, P4, and P5 showed very promising anti-quorum sensing activity on lasB-gfp reporter strain of Pseudomonas aeruginosa without affecting bacterial growth. Under our condition, these compounds also showed good anti-violacein production of Chromobacterium violaceum. In terms of antibiofilm formation, except P5, two β-turn mimetic-based peptides P1 and P4 showed maximum inhibition of 80% total biomass of Pseudomonas aeruginosa. This report provides the first β-turn mimetic-based scaffold for future drug development. 2021-09-13T04:24:47Z 2021-09-13T04:24:47Z 2021 Bài trích https://www.sciencedirect.com/science/article/abs/pii/S0960894X21003978?via%3Dihub https://dlib.phenikaa-uni.edu.vn/handle/PNK/2814 https://doi.org/10.1016/j.bmcl.2021.128170 eng Bioorganic & Medicinal Chemistry Letters
institution	Digital Phenikaa
collection	Digital Phenikaa
language	eng
topic	Synthesis Anti-biofilm Β-turn
spellingShingle	Synthesis Anti-biofilm Β-turn Truong Thanh Tung Thang Nguyen Quoc Discovery of novel β-turn mimetic-based peptides as novel quorum sensing inhibitors of gram-negative bacteria
description	To date, a very limited number of peptides reported as quorum sensing inhibitors. Herein, we report the synthesis and evaluation of a series of β-turn mimetic-based peptides as potent quorum sensing inhibitors and antibiofilm formation. In this series, peptides P1, P4, and P5 showed very promising anti-quorum sensing activity on lasB-gfp reporter strain of Pseudomonas aeruginosa without affecting bacterial growth. Under our condition, these compounds also showed good anti-violacein production of Chromobacterium violaceum. In terms of antibiofilm formation, except P5, two β-turn mimetic-based peptides P1 and P4 showed maximum inhibition of 80% total biomass of Pseudomonas aeruginosa. This report provides the first β-turn mimetic-based scaffold for future drug development.
format	Bài trích
author	Truong Thanh Tung Thang Nguyen Quoc
author_facet	Truong Thanh Tung Thang Nguyen Quoc
author_sort	Truong Thanh Tung
title	Discovery of novel β-turn mimetic-based peptides as novel quorum sensing inhibitors of gram-negative bacteria
title_short	Discovery of novel β-turn mimetic-based peptides as novel quorum sensing inhibitors of gram-negative bacteria
title_full	Discovery of novel β-turn mimetic-based peptides as novel quorum sensing inhibitors of gram-negative bacteria
title_fullStr	Discovery of novel β-turn mimetic-based peptides as novel quorum sensing inhibitors of gram-negative bacteria
title_full_unstemmed	Discovery of novel β-turn mimetic-based peptides as novel quorum sensing inhibitors of gram-negative bacteria
title_sort	discovery of novel β-turn mimetic-based peptides as novel quorum sensing inhibitors of gram-negative bacteria
publisher	Bioorganic & Medicinal Chemistry Letters
publishDate	2021
url	https://www.sciencedirect.com/science/article/abs/pii/S0960894X21003978?via%3Dihub https://dlib.phenikaa-uni.edu.vn/handle/PNK/2814 https://doi.org/10.1016/j.bmcl.2021.128170
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score	8.891787

Discovery of novel β-turn mimetic-based peptides as novel quorum sensing inhibitors of gram-negative bacteria

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